Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia
Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia
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雪松香味对阿尔茨海默型痴呆患者认知功能及行为心理症状的影响研究
DOI：
10.1002/npr2.12096
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发表时间：
2020
影响因子：
2.5
通讯作者：
Mishima Kazuo
中科院分区：
文献类型：
--
作者：
Takahashi Yuya;Shindo Sho;Kanbayashi Takashi;Takeshima Masahiro;Imanishi Aya;Mishima Kazuo
我们研究了阿尔茨海默型痴呆患者的嗅觉神经刺激是否能改善痴呆症状。首先，对阿尔茨海默型痴呆患者进行棒型嗅觉识别能力测试，以选择没有嗅觉功能障碍的患者。然后将这些患者随机分为干预组（n = 19）和对照组（n = 17）。为了评估嗅觉神经刺激的效果，我们将干预组暴露于添加香木提取物的消毒乙醇中，而对照组则暴露于不添加香木提取物的乙醇中。每组接受干预8周，治疗前后使用神经精神量表（NPI）、日文版Zarit护理者负担访谈（J - ZBI）和阿尔茨海默病评估量表-认知子量表（ADAS - cog）评估认知和行为功能。与对照组相比，干预组在第4周和第8周的NPI评分和J - ZBI有显著改善。另一方面，两组的ADAS - cog评分无显著差异。暴露于雪松香可改善阿尔茨海默型痴呆患者的行为和心理症状，并可能减轻护理负担。除其有效性外，该方法简单，微创，将是一种有价值的非药物治疗方法。
We examined whether symptoms of dementia are improved by olfactory nerve stimulation in Alzheimer type dementia patients. First, a stick‐type olfactory identification ability test was performed in patients with Alzheimer type dementia, to select patients without olfactory dysfunctions. Then, these patients were randomly assigned into the intervention (n = 19) and the control groups (n = 17). To evaluate the effects of olfactory nerve stimulation, we exposed the intervention group to a disinfecting ethanol with added aroma extracts from ceder and the control group to the ethanol without the added aroma extracts. Each group underwent the intervention for 8 weeks, cognitive and behavioral functions were evaluated before and after treatments using the Neuropsychiatric Inventory (NPI), the Japanese version of Zarit Caregiver Burden interview (J‐ZBI), and the Alzheimer's Disease Assessment Scale‐cognitive subscale (ADAS‐cog). A significant improvement was observed in the NPI score and J‐ZBI in the intervention group compared to the control group at 4 and 8 weeks. On the other hand, there was no significant difference in the score of ADAS‐cog. Exposure to cedar fragrance improved behavioral and psychological symptoms of dementia (BPSD) in Alzheimer type dementia and may reduce the burden of nursing care. In addition to its effectiveness, the procedure is simple and minimally invasive and would be a valuable non‐pharmaceutical treatment.