Pacemaker activity in septal structures of canine colonic circular muscle.
Pacemaker activity in septal structures of canine colonic circular muscle.
复制标题
犬结肠环肌间隔结构中的起搏器活动。
DOI：
10.1152/ajpgi.1990.259.2.g264
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Sanders,KM
中科院分区：
文献类型：
--
作者：
Ward,SM;Sanders,KM
对犬近端结肠环行肌的起搏区进行了形态和电生理实验研究。形态学研究显示，Cajal间质细胞排列在环形层的粘膜下表面和分隔环形层成束的间隔结构中。电学测量表明，慢波可能以一种再生的方式沿着环状肌肉的表面传播到环状肌肉的厚度。去除粘膜下起搏器区域阻止了环行肌非间隔区域慢波的产生，但慢波活动在间隔附近的环行肌中继续存在。这些数据表明，慢波起搏器的活动并不局限于粘膜下表面的二维表面，而是沿着间隔凹陷延伸到圆形层的内部。还进行了实验以确定起搏器活动的优势(即间隔与粘膜下)，并发现两个区域似乎都在完整肌肉中启动了慢波。其他研究表明，慢波可以通过隔膜传播，这表明环状肌束之间存在某种形式的电耦合。本研究提供了犬近端结肠起搏器区域的结构和功能的更完整的视图。
Morphological and electrophysiological experiments were performed to characterize the pacemaker areas of the circular muscle in the canine proximal colon. Morphological studies showed interstitial cells of Cajal lining the submucosal surface of the circular layer and the septal structures that separate the circular layer into bundles. Electrical measurements suggested that slow waves may propagate into the thickness of the circular muscle in a regenerative manner along the surface of these septa. Removal of the submucosal pacemaker region blocked generation of slow waves in nonseptal regions of the circular muscle, but slow-wave activity continued in the circular muscle near septa. These data suggest that slow-wave pacemaker activity is not limited to a two-dimensional surface at the submucosal surface but extends into the interior of the circular layer along septal invaginations. Experiments were also performed to determine the dominance of pacemaker activity (i.e., septal vs. submucosal), and examples were found in which both areas appeared to initiate slow waves in intact muscles. Other studies showed that slow waves could propagate across septa, suggesting some form of electrical coupling between circular muscle bundles. This study provides a more complete view of the structure and function of pacemaker areas in the canine proximal colon.