BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.
BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.
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作者：
Hutcheson J;Perlman H
类风湿性关节炎（RA）是一种使人衰弱的疾病，导致骨骼和软骨的破坏，以及关节的永久性毁容。虽然风湿性关节炎的确切病因目前尚不清楚，但已经清楚的是，炎症细胞的涌入和关节内促炎状态的升高所引起的毒性环境导致了破坏性影响。由于越来越多的文献表明，这种细胞优势是关节局部凋亡减少的结果，在这篇综述中，我们描述了Bcl-2家族促凋亡的BH3-only蛋白，特别是Bim和Bid，如何起作用，防止疾病的发展。我们还建议bh3模拟药物作为治疗RA的潜在治疗药物。
Rheumatoid arthritis (RA) is a debilitating disease resulting in the destruction of bone and cartilage, and the permanent disfigurement of joints. Although the precise cause of RA is currently unresolved, it has become clear that the damaging effects are a result of the toxic milieu caused by an influx of inflammatory cells and the resulting heightened pro-inflammatory state within the joint. As the amount of literature that suggests that this preponderance of cells is a result of decreased local apoptosis in the joint continues to increase, in this review we describe how Bcl-2 family pro-apoptotic BH3-only proteins, particularly Bim and Bid, could act to protect against the development of the disease. We also suggest a role for BH3-mimetic drugs as potential therapeutics in the treatment of RA.
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通讯作者：
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