Can hepatitis B core antibody positive livers be used safely for transplantation: hepatitis B virus detection in the liver of individuals who are hepatitis B core antibody positive.
Can hepatitis B core antibody positive livers be used safely for transplantation: hepatitis B virus detection in the liver of individuals who are hepatitis B core antibody positive.
复制标题
乙型肝炎核心抗体阳性肝脏能否安全用于移植：乙型肝炎核心抗体阳性个体肝脏中乙型肝炎病毒检测。
DOI：
10.1097/00007890-199908270-00013
复制
发表时间：
1999
期刊：
影响因子：
6.2
通讯作者：
L. Friedlander
中科院分区：
文献类型：
--
作者：
D. H. V. Thiel;N. D. Maria;A. Colantoni;L. Friedlander
临床肝移植广泛应用的一个主要障碍是缺乏可接受的器官。大多数中心拒绝来自B型肝炎核心抗体阳性的捐赠者的器官，因为担心将B型肝炎病毒（HBV）感染传播给接受者。从未以有序的方式评估与使用这类捐赠器官有关的风险。在133例连续患者中，对因临床原因接受肝活检的个体的肝组织中是否存在聚合酶链反应可检测的HBV-DNA进行了评估。这些肝脏中共有8.2%的结果为HBV-DNA阳性;有趣的是，与未检测到B型肝炎表面抗体的患者（5.7%）相比，B型肝炎表面抗体阳性的患者（12.5%）中HBV-DNA阳性率更高。这些数据提供了与使用从B型肝炎核心抗体阳性供体获得的器官相关的肝移植受者中HBV感染的推定风险的措施。
A major impediment to the wider application of clinical liver transplantation is the paucity of acceptable organs. Most centers refuse organs that come from donors who are hepatitis B core antibody positive because of a fear of transmission of hepatitis B virus (HBV) infection to the recipient. The risk related to the use of such donor organs has never been assessed in an ordered manner. The presence or absence of polymerase chain reaction detectable HBV-DNA in liver tissue of individuals undergoing liver biopsy for clinical reasons was assessed in 133 consecutive patients. A total of 8.2% of these livers resulted positive for HBV-DNA; interestingly the rate was higher among those who were hepatitis B surface antibody positive (12.5%) as compared to those without detectable hepatitis B surface antibody (5.7%). These data provide measures of putative risk for HBV infection in liver transplant recipients associated with the use of organs obtained from a hepatitis B core antibody positive donor.