A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model
A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model
复制标题
猕猴群体立体定位正电子发射断层扫描脑模板及其在缺血模型中的应用
DOI：
10.1016/j.neuroimage.2019.116163
复制
发表时间：
2019-12-01
期刊：
影响因子：
5.7
通讯作者：
Shan, Baoci
中科院分区：
文献类型：
--
作者：
Nie, Binbin;Wang, Lu;Shan, Baoci
目的：正电子发射断层扫描（PET）是一种非侵入性成像工具，用于评估正常和疾病条件下的脑功能和神经元活动，具有高灵敏度。猕猴是转化医学研究的重要模式动物，其系统发育与人类相似，因此需要一个有效、客观的神经PET数据分析平台，用于非人灵长类动物的神经PET研究。材料与方法：一套猕猴脑立体定位模板，即高能物理研究所&暨南大学猕猴模板（HJT），基于30只健康恒河猴，通过迭代配准和平均来构建。结果：HJT包括结构MRI T1加权成像（T1 WI）模板图像、功能FDG-PET模板图像、颅内组织分割和数字化猕猴脑图谱图像。它与各种商用软件工具兼容，如SPM和PMOD。数据分析进行了中风模型与一组健康对照组相比，以证明使用HJT.Conclusion：我们已经构建了一个立体定位模板集猕猴脑命名HJT，whitestrizes猕猴神经影像学数据分析，支持新的放射性示踪剂的开发和促进翻译神经疾病的研究。
Purpose: Positron emission tomography (PET) is a non-invasive imaging tool for the evaluation of brain function and neuronal activity in normal and diseased conditions with high sensitivity. The macaque monkey serves as a valuable model system in the field of translational medicine, for its phylogenetic proximity to man. To translation of non-human primate neuro-PET studies, an effective and objective data analysis platform for neuro-PET studies is needed.Materials and methods: A set of stereotaxic templates of macaque brain, namely the Institute of High Energy Physics & Jinan University Macaque Template (HJT), was constructed by iteratively registration and averaging, based on 30 healthy rhesus monkeys. A brain atlas image was created in HJT space by combining sub-anatomical regions and defining new 88 bilateral functional regions, in which a unique integer was assigned for each sub-anatomical region.Results: The HJT comprised a structural MRI T1 weighted image (T1WI) template image, a functional FDG-PET template image, intracranial tissue segmentations accompanied with a digital macaque brain atlas image. It is compatible with various commercially available software tools, such as SPM and PMOD. Data analysis was performed on a stroke model compared with a group of healthy controls to demonstrate the usage of HJT.Conclusion: We have constructed a stereotaxic template set of macaque brain named HJT, which standardizes macaque neuroimaging data analysis, supports novel radiotracer development and facilitates translational neuro-disorders research.