Relation Between Red Cell Distribution Width and Clinical Outcomes After Acute Myocardial Infarction
Relation Between Red Cell Distribution Width and Clinical Outcomes After Acute Myocardial Infarction
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DOI：
10.1016/j.amjcard.2009.09.027
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发表时间：
2010-02-01
影响因子：
2.8
通讯作者：
Aronson, Doron
中科院分区：
文献类型：
--
作者：
Dabbah, Saleem;Hammerman, Haim;Aronson, Doron
红细胞分布宽度（RDW）增加与心力衰竭和稳定性冠状动脉疾病的不良结局相关。我们研究了急性心肌梗死（AMI）患者基线RDW和住院期间RDW变化与临床结局之间的关系。在1,709例AMI患者中测定了基线RDW和住院期间RDW的变化，这些患者的随访时间中位数为27个月（范围6至48）。使用考克斯回归模型，校正临床变量、基线血红蛋白、平均红细胞体积和左心室射血分数，检验RDW和出院后临床结局之间的关系。与第一个RDW五分位数中的患者相比，随着RDW五分位数的增加，校正后的死亡风险比逐渐增加（第二个五分位数1.1，95%置信区间[CI] 0.6至2.1;第三个五分位数1.8，95% CI 1.0至3.2;第四个五分位数2.0，95% CI 1.1至3.4;第五个五分位数2.8，95%置信区间1.6至4.7，趋势p
Increased red blood cell distribution width (RDW) has been associated with adverse outcomes in heart failure and stable coronary disease. We studied the association between baseline RDW and changes in RDW during hospital course with clinical outcomes in patients with acute myocardial infarction (AMI). Baseline RDW and RDW change during hospital course were determined in 1,709 patients with AMI who were followed for a median of 27 months (range 6 to 48). The relation between RDW and clinical outcomes after hospital discharge were tested using Cox regression models, adjusting for clinical variables, baseline hemoglobin, mean corpuscular volume, and left ventricular ejection fraction. Compared to patients in the first RDW quintile, the adjusted hazard ratios for death progressively increased with higher quintiles of RDW (second quintile 1.1, 95% confidence interval [CI] 0.6 to 2.1; third quintile 1.8, 95% CI 1.0 to 3.2; fourth quintile 2.0, 95% CI 1.1 to 3.4; fifth quintile 2.8, 95% CI 1.6 to 4.7, p for trend