Dissociating the Neural Correlates of Planning and Executing Tasks with Nested Task Sets.
Dissociating the Neural Correlates of Planning and Executing Tasks with Nested Task Sets.
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将计划和执行任务的神经关联与嵌套任务集分离。
DOI：
10.1162/jocn_a_01837
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发表时间：
2022
影响因子：
3.2
通讯作者：
Schumacher,EricH
中科院分区：
文献类型：
--
作者：
Cookson,SavannahL;Schumacher,EricH
任务处理（如反应的准备和执行）和任务表征（如刺激反应和上下文信息的激活和维持）是侧额叶皮层（LFC）支持认知控制的两个方面。然而，这两个方面之间的机制重叠（或区别）是未知的。我们通过将复杂的任务映射与前置过程相结合来探索这一点。在fMRI记录过程中，参与者对成对的刺激进行匹配/不匹配判断。每次试验的提示都给预期刺激的参与者提供了不同数量的信息。我们的研究结果表明，整个LFC区域在刺激（当可以执行响应时）比在提示（当只能准备响应时）更活跃，这表明它们支持执行与特定任务表征无关的任务。左尾侧LFC的一部分区域在提示信息增多时活动增加，而在刺激信息增多时活动增加，这表明它们参与了减少任务表征中的不确定性。这些结果表明，任务处理的一个组成部分是根据相关表征准备和执行任务，该表征仅限于左尾侧LFC，而主要在执行过程中发生的非表征功能则由其余LFC的不同区域支持。在本研究中，我们进一步对两组区域之间的连通性及其与额顶叶和扣谷-眼网络的潜在关系进行了探索性研究。具有两种活动模式的区域似乎是额顶叶网络的一部分。
Task processing (e.g., the preparation and execution of responses) and task representation (e.g., the activation and maintenance of stimulus–response and context information) are two facets of cognitive control supported by lateral frontal cortex (LFC). However, the mechanistic overlap (or distinction) between these two facets is unknown. We explored this by combining a complex task mapping with a precueing procedure. Participants made match/nonmatch judgments on pairs of stimuli during fMRI recording. Precues on each trial gave variable amounts of information to the participant in anticipation of the stimulus. Our results demonstrated that regions throughout LFC were more active at the stimulus (when responses could be executed) than at the cue (when they could only be prepared), indicating that they supported execution of the task agnostic to the specific task representation. A subset of regions in the left caudal LFC showed increased activity with more cue information at the cue and the reverse at the stimulus, suggesting their involvement in reducing uncertainty within the task representation. These results suggest that one component of task processing is preparing and executing the task according to the relevant representation, confined to left caudal LFC, whereas nonrepresentational functions that occur primarily during execution are supported by different regions throughout the rest of LFC. We further conducted an exploratory investigation of connectivity between the two groups of regions in this study and their potential relationship to the frontoparietal and cingulo-opercular networks. Regions with both patterns of activity appear to be part of the frontoparietal network.