CHEMICAL ECOLOGY OF CANARIAN LAUREL FOREST - TOXIC DITERPENES FROM PERSEA-INDICA (LAURACEAE)
CHEMICAL ECOLOGY OF CANARIAN LAUREL FOREST - TOXIC DITERPENES FROM PERSEA-INDICA (LAURACEAE)
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DOI：
10.1007/bf00988081
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发表时间：
1990-09-01
影响因子：
2.3
通讯作者：
FRAGA, BM
中科院分区：
文献类型：
--
作者：
GONZALEZCOLOMA, A;HERNANDEZ, MG;FRAGA, BM
树种P. indica（月桂科）是加那利群岛月桂林中的一种重要的特有植物，由于野生老鼠（Rattus Rattus）的季节性活动，它的落叶外观很容易被区分出来，这些老鼠吃了这种植物并变得中毒。这些观察结果和对这种植物的植物化学兴趣促使我们研究导致这种作用的潜在有毒化学物质。我们发现，对实验小鼠进行注射时，籼稻的乙醇提取物及其水馏分具有毒性。小鼠在摄入茎后也会死亡，与水对照组相比，小鼠对提取后用8%的水提取物溶液再水化的茎表现出明显的偏好。从毒性部分中分离出两种化合物，并通过光谱方法鉴定为多羟基五环二萜良烷醇和肉桂醇。讨论了可能的生态影响。
The tree species P. indica (Lauraceae) is an important endemism in the Canary Islands laurel forest and can readily be distinguished by its defoliated appearance due to the seasonal action of wild rats (Rattus rattus), which eat the plant and become intoxicated. These observations and the phytochemical interest of this plant species led us to study the potentially toxic chemicals responsible for such action. We found that an ethanolic extract of P. indica and its water fraction were toxic when injected into laboratory mice. The mice also died after ingestion of the stems and showed a significant preference for those extracted and rehydrated with an 8% aqueous extract solution when compared with the water control. Two compounds that have been isolated from the toxic fraction and identified by spectroscopic methods are the polyhydroxy pentacyclic diterpenes ryanodol and cinnceylanol. Possible ecological implications are discussed.