Efficacy of different intraocular lens materials and optic edge designs in preventing posterior capsular opacification: A meta-analysis
Efficacy of different intraocular lens materials and optic edge designs in preventing posterior capsular opacification: A meta-analysis
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DOI：
10.1016/j.ajo.2006.11.045
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发表时间：
2007-03-01
影响因子：
4.2
通讯作者：
Ma, Xiao-Ye
中科院分区：
文献类型：
--
作者：
Cheng, Jin-Wei;Wei, Rui-Li;Ma, Xiao-Ye
中心点目的。评价不同人工晶状体（IOL）材料和晶状体边缘设计预防后囊膜混浊（PCO）的效果。设计：系统回顾和荟萃分析。方法：通过Cochrane图书馆、MEDLINE和Embase的电子检索选择相关研究。通过meta分析对符合预定标准的随机对照试验进行系统评价。以风险差异衡量治疗效果，并根据随机效应模型计算汇总估计值。结果：本meta分析共纳入23项随机对照试验。与聚甲基丙烯酸甲酯（PNMA）镜片相比，Nd:YAG激光囊切开术的总风险差异为-24%(95%可信区间[CI]， -29%至-20%)；-9% （95% CI， -17%至-1%）硅胶与PMMA镜片的比较；14% （95% CI， -8%至36%）比较水凝胶和PMMA镜片；4% （95% CI， -2%至10%）的人比较硅胶和丙烯酸镜片；19% （95% CI, 8% - 30%）比较水凝胶和丙烯酸镜片；28% （95% CI, 10% - 46%）的人比较水凝胶和硅胶镜片。与丙烯酸镜片和PMMA镜片相比，PCO发生率的总风险差异为-39% (95% CI， -47%至-31%)；-14% （95% CI， -29%至0%）的人将硅胶镜片与丙烯酸镜片进行比较；56% （95% CI, 36% - 75%）比较水凝胶和丙烯酸镜片；48% （95% CI, 31% - 64%）的人比较水凝胶和硅胶镜片。当比较尖锐与圆形边缘设计时，PMMA镜片的囊膜切开率的总风险差异为-47% (95% CI， -77%至-17%)，丙烯酸镜片为-22% (95% CI， -47%至2%)，硅胶镜片为-9% (95% CI， -17%至0%)；丙烯酸镜片的PCO发生率的总风险差异为-28% (95% CI， -50%至-7%)，硅胶镜片的总风险差异为-37% （95% CI， -46%至-27%）。结论：不同的人工晶状体生物材料和光学边缘设计可能影响PCO和Nd:YAG激光囊切开术的成功率。丙烯酸和硅树脂制成的晶状体以及具有锐利光学边缘的晶状体在降低PCO和激光囊切开术发生率方面具有优势。
center dot PURPOSE. To evaluate the efficacy of different intraocular lens (IOL) materials and optic edge designs in preventing posterior capsular opacification (PCO). center dot DESIGN: Systematic review and meta-analysis.center dot METHODS: Pertinent studies were selected through an electronic search of the Cochrane Library, MEDLINE, and Embase. The randomized controlled trials meeting the predefined criteria were reviewed systematically by meta,analysis. The treatment effects were measured as risk difference, and the pooled estimates were computed according to a random effect model.center dot RESULTS: In total, 23 randomized controlled trials were included in the present meta-analysis. The pooled risk differences of Nd:YAG laser capsulotomy rates were -24% (95% confidence interval [CI], -29% to -20%) comparing acrylic with polymethylmethacrylate (PNMA) lenses; -9% (95% CI, -17% to -1%) comparing silicone with PMMA lenses; 14% (95% CI, -8% to 36%) comparing hydrogel with PMMA lenses; 4% (95% CI, -2% to 10%) comparing silicone with acrylic lenses; 19% (95% CI, 8% to 30%) comparing hydrogel with acrylic lenses; and 28% (95% CI, 10% to 46%) comparing hydrogel with silicone lenses. The pooled risk differences of PCO rates were -39% (95% CI, -47% to -31%) comparing acrylic with PMMA lenses; -14% (95% CI, -29% to 0%) comparing silicone with acrylic lenses; 56% (95% CI, 36% to 75%) comparing hydrogel with acrylic lenses; and 48% (95% CI, 31% to 64%) comparing hydrogel with silicone lenses. When comparing sharp with rounded,edge designs, pooled risk differences of capsulotomy rates were -47% (95% CI, -77% to -17%) in PMMA lenses, -22% (95% CI, -47% to 2%) in acrylic lenses, and -9% (95% CI, -17% to 0%) in silicone lenses; pooled risk differences of PCO rates were -28% (95% CI, -50% to -7%) in acrylic lenses and -37% (95% CI, -46% to -27%) in silicone lenses.center dot CONCLUSIONS: The rates of PCO and Nd:YAG laser capsulotomy may be influenced by different IOL biomaterials and optic edge designs. The lenses made by acrylic and silicone and those with sharp optic edges are superior in lowering the rates of PCO and laser capsulotomy.