Iridium-catalyzed Asymmetric Hydrogenation of Pyridinium Salts for Constructing Multiple Stereogenic Centers on Piperidines
Iridium-catalyzed Asymmetric Hydrogenation of Pyridinium Salts for Constructing Multiple Stereogenic Centers on Piperidines
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DOI：
10.1246/cl.130943
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发表时间：
2014-03-05
影响因子：
1.6
通讯作者：
Mashima, Kazushi
中科院分区：
文献类型：
--
作者：
Kita, Yusuke;Iimuro, Atsuhiro;Mashima, Kazushi
本文介绍了吡啶不对称氢化的成盐策略。用手性铱双核配合物对多取代吡啶盐进行氢化，经过简单的碱性处理，得到了具有多个立体异构中心的取代哌啶。
A salt formation strategy for asymmetric hydrogenation of pyridines is described. Poly-substituted pyridinium salts were successfully hydrogenated using chiral iridium dinuclear complexes to afford substituted piperidines with multiple stereogenic centers after a simple basic workup.