BODY CELL MASS AND LIMITS OF HYDRATION OF FAT-FREE BODY - THEIR RELATION TO ESTIMATED SKELETAL WEIGHT
BODY CELL MASS AND LIMITS OF HYDRATION OF FAT-FREE BODY - THEIR RELATION TO ESTIMATED SKELETAL WEIGHT
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DOI：
10.1111/j.1749-6632.1963.tb17072.x
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发表时间：
1963-01-01
期刊：
影响因子：
--
通讯作者：
BOYDEN, CM
中科院分区：
文献类型：
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作者：
MOORE, FD;BOYDEN, CM
根据这些实验室开发的方案，身体细胞质量（BCM）是能量交换、工作表现和有丝分裂潜力的有价值的“核心”参考标准。BCM的测量是基于总可交换钾，使用原始数据Ke，将其校正为细胞外钾，或者，如果需要，将Ke（单位为mEq）乘以一个系数，以产生以kg为单位的体细胞质量估计值。该系数可能介于7.5和9.5之间。在这项工作中，作为第一近似，使用8.33。无脂体的水合作用极限必须在两个边界内确定[长虚线]：一方面，无脂体的体重变化仅仅是由于机体细胞的减少或增加，另一方面，无脂体的体重变化仅仅是由于细胞外水的减少或增加。在这两个边界之间，当观察到的细胞外水与患病前个体中估计的细胞外水的关系已知时，就有可能定位水合作用。下面给出了一个基于这些考虑的图。由此得出无脂体的水合作用估计值，该估计值与仅因水分快速积累或流失而导致体重快速变化的患者的数值密切吻合。验证最终将需要尸体分析。同样，可以使用干骨基质的重量加上矿物质作为定义来构建估计骨骼重量的nomogram。这个图是基于这样一个事实，即相对骨骼重量似乎与Ke/FFS比成反比。这种关系的合理性是基于这样一个事实，即骨骼和其他细胞外组织固体重而致密，含有基本上不含钾的无脂肪固体。随着固定尺寸骨架周围的体细胞质量和体脂的消耗，骨架的Ke /FFS下降，骨架的相对重量上升。使用这个nomogram可以得到相对骨骼重量的第一个估计，这在这个概念框架内是有用的。这也只有在人类的尸体分析中才能得到最终的证实。
According to the scheme developed in these laboratories the body cell mass (BCM) is a valuable "core" reference standard for energy exchange, work performance, and mitotic potential. The measurement of the BCM is based on the total exchangeable potassium using either the raw data Ke, correcting it for the extracellular potassium, or, if desired, multiplying the Ke (in mEq.) by a coefficient to yield an estimate of body cell mass in kg. This coefficient probably lies between 7.5 and 9.5. In this work, as a first approximation, 8.33 was used. The limits of hydration of the fatfree body must be definable within two boundaries[long dash]change of weight of the fat-free body by loss or gain of body cells alone on the one hand, and change of weight of the fat-free body by loss or gain of extracellular water alone on the other. Between these two boundaries it is possible to locate the hydration when the relation of the observed extracellular water to the estimated extracellular water in that individual prior to illness is known. A nomogram based on these considerations is shown. This yields an estimate for the hydration for the fat-free body which checks closely with values obtained in patients in whom rapid weight changes are due to rapid accumulation or loss of water alone. Validation ultimately will require cadaver analysis. Similarly, it is possible to construct a nomogram for the estimated skeletal weight using the weight of dry bone matrix plus mineral as the definition. This nomogram is based on the fact that the relative skeletal weight appears to vary inversely with the Ke/FFS ratio. The rationality of this relationship is based on the fact that the skeleton and other extracellular tissue solids are heavy and dense, containing fat-free solids that are essentially free of potassium. As the body cell mass and body fat waste around a skeleton of fixed size the Ke /FFS falls and the relative weight of the skeleton rises. The use of this nomogram derives a first estimate for relative skeletal weight which has been useful within this conceptual framework. This also will find ultimate validation only from cadaver analysis in man.