PRESSURE EVENTS SURROUNDING ESOPHAGEAL ACID REFLUX EPISODES AND ACID CLEARANCE IN AMBULANT HEALTHY-VOLUNTEERS
PRESSURE EVENTS SURROUNDING ESOPHAGEAL ACID REFLUX EPISODES AND ACID CLEARANCE IN AMBULANT HEALTHY-VOLUNTEERS
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DOI：
10.1136/gut.34.4.444
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发表时间：
1993-04-01
期刊：
影响因子：
24.5
通讯作者：
ALDERSON, D
中科院分区：
文献类型：
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作者：
BARHAM, CP;GOTLEY, DC;ALDERSON, D
以前的研究机制，沉淀酸反流发作和酸清除使用非生理性，短期的医院为基础的数据。一种新的24小时pH值和运动记录系统结合计算机数据分析已被用来研究自然发生的酸反流事件在健康的流动志愿者。产生可识别的经颅压模式的各种事件与胃酸反流发作（特别是打嗝）相关。蠕动波是导致食管酸清除的主要收缩，也是反流发作期间最常见的收缩类型。蠕动波参数（振幅、速度、频率和百分比）在24小时记录的不同时间段内变化。这项研究产生了关于24小时食管功能和自然发生的酸反流的新信息，这将为与胃食管反流病患者进行比较提供依据。
Previous studies of the mechanisms that precipitate acid reflux episodes and acid clearance have used unphysiological, short term hospital based data. A new 24 hour pH and motility recording system combined with computerised data analysis have been used to study naturally occurring acid reflux episodes in healthy ambulant volunteers. A variety of events that produced recognisable transdiaphragmatic pressure patterns were associated with acid reflux episodes (particularly belching). Peristaltic waves were the predominant contractions leading to oesophageal acid clearance and were the commonest contraction type during reflux episodes. Peristaltic wave parameters (amplitude, velocity, frequency, and percentage proportion) varied during different periods of the 24 hour recording. This study has produced new information about 24 hour oesophageal function and naturally occurring acid reflux which will provide a basis for comparison with patients with gastro-oesophageal reflux disease.