Postnatal maturation of auditory-nerve heterogeneity, as seen in spatial gradients of synapse morphology in the inner hair cell area.
Postnatal maturation of auditory-nerve heterogeneity, as seen in spatial gradients of synapse morphology in the inner hair cell area.
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DOI：
10.1016/j.heares.2016.06.002
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发表时间：
2016-09
期刊：
影响因子：
2.8
通讯作者：
Liberman, M. Charles
中科院分区：
文献类型：
--
作者：
Liberman, Leslie D.;Liberman, M. Charles
根据听神经纤维的自发频率(SR)和阈值敏感度，将成人耳内的听神经纤维分为功能亚群。高阈值、低SR纤维在形态和空间上与低阈值高SR纤维在与内毛细胞的突触接触上是不同的。在共聚焦显微镜下可以看到，在成人耳中，突触前带和突触后谷氨酸受体斑块的大小梯度互补，横跨内毛细胞区的外侧柱和缰毛-角质轴。本研究的目的是追踪这种形态梯度在小鼠出生后的发育，以确定这一重要方面的耳蜗组织完全成熟的最早年龄。在这里，我们通过对Corti器官的形态计量学分析，发现这种基于SR的形态梯度直到出生后第28天才完全建立，而其他特征，如内、外毛细胞区的突触计数和传出神经密度，似乎完全成熟。
Auditory nerve fibers in the adult ear are divided into functional subgroups according to spontaneous rate (SR) and threshold sensitivity. The high-threshold, low-SR fibers are morphologically and spatially distinct from the low-threshold high-SR fibers at their synaptic contacts with inner hair cells. This distinction between SR groups in the adult ear is visible in confocal microscopy as complementary size gradients of presynaptic ribbons and post-synaptic glutamate receptor patches across the modiolar-pillar and habenular-cuticular axes in the inner hair cell area. The aim of the present study was to track the post-natal development of this morphological gradient, in mouse, to determine the earliest age at which this important aspect of cochlear organization is fully mature. Here we show, using morphometric analysis of the organ of Corti immunostained for pre- and post-synaptic markers of efferent and afferent innervation, that this SR-based morphological gradient is not fully established until postnatal day 28, well after other features, such as synaptic counts and efferent innervation density in both the inner and outer hair cell areas, appear fully mature.
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DOI：
10.1523/jneurosci.3389-10.2011
发表时间：
2011-01-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liberman LD;Wang H;Liberman MC
通讯作者：
Liberman MC
影响因子：
3.3
作者：
Liu Q;Lee E;Davis RL
通讯作者：
Davis RL
影响因子：
2.8
作者：
LIBERMAN, MC
通讯作者：
LIBERMAN, MC
影响因子：
16.2
作者：
Frank, Thomas;Rutherford, Mark A.;Strenzke, Nicola;Neef, Andreas;Pangrsic, Tina;Khimich, Darina;Fetjova, Anna;Gundelfinger, Eckart D.;Liberman, M. Charles;Harke, Benjamin;Bryan, Keith E.;Lee, Amy;Egner, Alexander;Riedel, Dietmar;Moser, Tobias
通讯作者：
Moser, Tobias
DOI：
10.1073/pnas.1515228112
发表时间：
2015-11-24
影响因子：
11.1
作者：
Liu, Chang;Glowatzki, Elisabeth;Fuchs, Paul Albert
通讯作者：
Fuchs, Paul Albert