Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
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DOI：
10.1038/nn1003
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发表时间：
2003-02-01
影响因子：
25
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Aron, AR;Fletcher, PC;Robbins, TW
执行功能的精确定位，如前额叶皮层（PFC）内的反应抑制，虽然理论上至关重要，但已被证明是有争议和困难的。功能性神经影像学对这一争论做出了重要贡献，我们克服了这一局限性，使用一种新的独立于大脑皮层的方法，将特定前额叶区域内的损伤程度与停止信号任务的表现联系起来，该任务对停止行为的神经发育方面和注意力缺陷/多动障碍（ADHD）以及哌甲酯的改善敏感。
The precise localization of executive functions such as response inhibition within the prefrontal cortex (PFC), although theoretically crucial, has proven to be controversial and difficult. Functional neuroimaging has contributed importantly to this debate,,,,,,, but as human cortical lesions are seldom discrete, the literature still lacks definitive neuropsychological evidence that a specific region is necessary for task performance. We overcame this limitation by using a new observer-independent method to relate the degree of damage within a specific prefrontal region to performance on a stop-signal task that is sensitive to the neurodevelopmental aspects of stopping behavior and to attention-deficit/hyperactivity disorder (ADHD) as well as its amelioration by methylphenidate,.