IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance.
IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance.
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DOI：
10.1016/j.cyto.2015.05.005
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发表时间：
2015-10
期刊：
影响因子：
3.8
通讯作者：
van Diepen JA
中科院分区：
文献类型：
--
作者：
Ballak DB;Stienstra R;Tack CJ;Dinarello CA;van Diepen JA
肥胖的特征是慢性低度炎症，导致胰岛素抵抗和2型糖尿病的发展。免疫活性细胞产生的细胞因子和趋化因子影响局部和全身炎症，因此是2型糖尿病发病机制的关键因素。因此，调节炎症反应的细胞因子正在成为干预和治疗肥胖代谢后果的潜在靶点。白介素1(IL-1)家族的细胞因子和受体是先天炎症反应的关键介质，具有促炎和抗炎功能。在过去的几十年里，对IL-1家族如何影响肥胖诱导的胰岛素抵抗的启动和进展的机械论见解显著增加。在这里，我们回顾了目前的知识和理解，重点是IL-1细胞因子家族的个别成员在改善糖尿病患者胰岛素敏感性方面的治疗潜力。
Obesity is characterized by a chronic, low-grade inflammation that contributes to the development of insulin resistance and type 2 diabetes. Cytokines and chemokines produced by immunocompetent cells influence local as well as systemic inflammation and are therefore critical contributors to the pathogenesis of type 2 diabetes. Hence, cytokines that modulate inflammatory responses are emerging as potential targets for intervention and treatment of the metabolic consequences of obesity. The interleukin-1 (IL-1) family of cytokines and receptors are key mediators of innate inflammatory responses and exhibit both pro- and anti-inflammatory functions. During the last decades, mechanistic insights into how the IL-1 family affects the initiation and progression of obesity-induced insulin resistance have increased significantly. Here, we review the current knowledge and understanding, with emphasis on the therapeutic potential of individual members of the IL-1 family of cytokines for improving insulin sensitivity in patients with diabetes.