Simple and practical routes to enantiomerically pure 5-(trialkylsilyl)-2-cyclohexenones
Simple and practical routes to enantiomerically pure 5-(trialkylsilyl)-2-cyclohexenones
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DOI：
10.1021/ol990805f
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发表时间：
1999-09-09
期刊：
影响因子：
5.2
通讯作者：
Corey, EJ
中科院分区：
文献类型：
--
作者：
Sarakinos, G;Corey, EJ
[GRAPHICS]Enantiomerically pure chiral 5-silylated 2-cyclohexenones are easily prepared in high yield using as a key step kinetic resolution with a commercially available lipase. Fully active enzyme can be recovered very efficiently for reuse. The synthetic steps are outlined in Schemes 1 and 3. Enantiomerically pure 2 cyclohexenones such as 1 and 2 are versatile intermediates for the synthesis of a multitude of chiral targets by means of a variety of diastereoselective reactions such as those illustrated in Scheme 2.
