Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease.
Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease.
复制标题
DOI：
--
复制
发表时间：
1999-04
期刊：
影响因子：
3.4
通讯作者：
J. Gorell;C. Johnson;B. Rybicki;Edward L. Peterson;G. Kortsha;G. G. Brown-G.;R. Richardson
中科院分区：
文献类型：
--
作者：
J. Gorell;C. Johnson;B. Rybicki;Edward L. Peterson;G. Kortsha;G. G. Brown-G.;R. Richardson
在底特律大都市的亨利福特卫生系统（HFHS）进行了一项基于人群的病例对照研究，以评估职业暴露于锰、铜、铅、铁、汞和锌作为帕金森病（PD）的危险因素。招募了在HFHS接受初级医疗护理的50岁非痴呆男性和女性，同时招募的病例（n = 144）和对照组（n = 464）在性别、种族和年龄（+/- 5岁）方面进行频率匹配。风险因素问卷调查，由受过训练的面试官管理，询问每一个主题举行的每一个工作6个月从18岁起，包括实际工作任务，工具和环境的详细评估。一位经验丰富的工业卫生学家，对受试者的病例对照状态不知情，使用这些数据来评估每一份工作是否暴露于一种或多种感兴趣的金属。调整性别，种族，年龄和吸烟状况，20年的职业暴露于任何金属与PD无关。然而，锰（OR = 10.61，95%CI = 1.06，105.83）或铜（OR = 2.49，95%CI = 1.06，5.89）暴露超过20年与PD相关。职业性接触铅-铜（OR = 5.24，95% CI = 1.59，17.21）、铅-铁（OR = 2.83，95% CI = 1.07，7.50）和铁-铜（OR = 3.69，95% CI = 1.40，9.71）也与该病有关。没有发现铁、汞或锌的职业暴露与PD相关。缺乏统计功效排除了对低暴露流行率（即，锰、汞和锌）。我们的研究结果表明，慢性职业暴露于锰或铜，单独或铅，铁和铜的双重组合，与PD。
A population-based case-control study was conducted in the Henry Ford Health System (HFHS) in metropolitan Detroit to assess occupational exposures to manganese, copper, lead, iron, mercury and zinc as risk factors for Parkinson's disease (PD). Non-demented men and women 50 years of age who were receiving primary medical care at HFHS were recruited, and concurrently enrolled cases (n = 144) and controls (n = 464) were frequency-matched for sex, race and age (+/- 5 years). A risk factor questionnaire, administered by trained interviewers, inquired about every job held by each subject for 6 months from age 18 onward, including a detailed assessment of actual job tasks, tools and environment. An experienced industrial hygienist, blinded to subjects' case-control status, used these data to rate every job as exposed or not exposed to one or more of the metals of interest. Adjusting for sex, race, age and smoking status, 20 years of occupational exposure to any metal was not associated with PD. However, more than 20 years exposure to manganese (Odds Ratio [OR] = 10.61, 95% Confidence Interval [CI] = 1.06, 105.83) or copper (OR = 2.49, 95% CI = 1.06,5.89) was associated with PD. Occupational exposure for > 20 years to combinations of lead-copper (OR = 5.24, 95% CI = 1.59, 17.21), lead-iron (OR = 2.83, 95% CI = 1.07,7.50), and iron-copper (OR = 3.69, 95% CI = 1.40,9.71) was also associated with the disease. No association of occupational exposure to iron, mercury or zinc with PD was found. A lack of statistical power precluded analyses of metal combinations for those with a low prevalence of exposure (i.e., manganese, mercury and zinc). Our findings suggest that chronic occupational exposure to manganese or copper, individually, or to dual combinations of lead, iron and copper, is associated with PD.