Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users
Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users
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DOI：
10.1016/j.pscychresns.2007.01.008
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发表时间：
2007-08-15
影响因子：
2.3
通讯作者：
Renshaw, Perrv F.
中科院分区：
文献类型：
--
作者：
Cowan, Ronald L.;Bolo, Nicolas R.;Renshaw, Perrv F.
娱乐药物MDMA(3，4，亚甲基二氧基甲基苯丙胺；以摇头丸的街头名称出售)对某些MDMA给药动物模型的5-羟色胺能轴突有毒性。在人类中，MDMA的使用与大脑功能标记物的变化有关，这些标记物在枕叶皮质明显。在神经成像方法中，在1.5特斯拉(T)的场强下，对大脑代谢物N-乙酰天冬氨酸(NAA)和肌醇(MI)的磁共振波谱(MRS)研究显示，MDMA使用者的结果不一致。由于高场强质子MRS在理论上比低场强具有优势，我们在4.0T使用质子MRS研究了中度MDMA使用者(n=9)和非MDMA使用者(n=7)的枕叶皮质NAA和MI的绝对浓度。非MDMA使用者平均NAA为10.47 mm(+/-2.5 1)，MDMA使用者为9.83 mm(+/-1.94)。非MDMA使用者的平均MI为7.43 mm(+/-0.68)，而MDMA使用者为6.57 mm(+/-1.59)。MDMA使用者和对照组枕叶皮质NAA和MI的绝对代谢物水平无统计学差异。这些发现不支持MDMA引起的NAA或MI水平的改变，在这个中等MDMA使用者的小样本中。这项研究的局限性表明，在解释这些结果时要谨慎。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
The recreational drug MDMA (3,4, methylenedioxymethamphetamine; sold under the street name of Ecstasy) is toxic to serotonergic axons in some animal models of MDMA administration. In humans, MDMA use is associated with alterations in markers of brain function that are pronounced in occipital cortex. Among neuroimaging methods, magnetic resonance spectroscopy (MRS) studies of brain metabolites N-acetylaspartate (NAA) and myoinositol (MI) at a field strength of 1.5 Tesla (T) reveal inconsistent results in MDMA users. Because higher field strength proton MRS has theoretical advantages over lower field strengths, we used proton MRS at 4.0 T to study absolute concentrations of occipital cortical NAA and MI in a cohort of moderate MDMA users (n = 9) versus non-MDMA using (n = 7) controls. Mean NAA in non-MDMA users was 10.47 mM ( +/- 2.5 1), versus 9.83 mM ( +/- 1.94) in MDMA users. Mean MI in non-MDMA users was 7.43 mM (+/-.68), versus 6.57 mM ( +/- 1.59) in MDMA users. There were no statistical differences in absolute metabolite levels for NAA and MI in occipital cortex of MDMA users and controls. These findings are not supportive of MDMA-induced alterations in NAA or MI levels in this small sample of moderate MDMA users. Limitations to this study suggest caution in the interpretation of these results. (c) 2007 Elsevier Ireland Ltd. All rights reserved.