Effect of human leukocyte antigen compatibility on kidney graft survival:: Comparative analysis of two decades
Effect of human leukocyte antigen compatibility on kidney graft survival:: Comparative analysis of two decades
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DOI：
10.1097/01.tp.0000269725.74189.b9
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发表时间：
2007-07-27
期刊：
影响因子：
6.2
通讯作者：
Doehler, Bernd
中科院分区：
文献类型：
--
作者：
Opelz, Gerhard;Doehler, Bernd
背景。根据器官共享联合网络数据分析，有报道称近年来人类白细胞抗原（HLA）配型在肾移植中的影响有所减弱，提示应修订供肾分配算法。我们使用协作移植研究的数据比较了 1985-1994 和 1995-2004 几十年间 HLA 匹配对肾移植存活的影响。另外还单独分析了过去5年（2000-2004）的结果。使用多元 Cox 回归分析来解释混杂因素的影响。结果。我们的结果表明，虽然随着时间的推移，移植物存活率总体有所提高，但 HLA 匹配对移植物存活率的相对影响仍然很大且非常显着。无论分析的时间间隔如何，移植后排斥治疗的需要和移植物存活率都显示出与 HLA 匹配具有统计学上高度显着的相关性（P
Background. Based on an analysis of United Network for Organ Sharing data, it was reported that the influence of human leukocyte antigen (HLA) matching in renal transplantation has diminished in recent years, prompting the suggestion that donor kidney allocation algorithms should be revised.Methods. We compared the impact of HLA matching on kidney graft survival during the decades 1985-1994 and 1995-2004 using the data of the Collaborative Transplant Study. Results for the last 5 years (2000-2004) were analyzed separately in addition. Multivariate Cox regression analysis was used to account for the influence of confounders.Results. Our results show that, while graft survival rates have improved overall over time, the relative impact of HLA matching on the graft survival rate has remained strong and highly significant. Both the need for posttransplant rejection treatment and the graft survival rates showed statistically highly significant associations with HLA matching regardless of the interval analyzed (P