Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents
Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents
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高甘油三酯血症和高尿酸血症：城市居民的回顾性研究
DOI：
10.1186/s12944-019-1031-6
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发表时间：
2019-04-01
影响因子：
4.5
通讯作者：
You, Chong-ge
中科院分区：
文献类型：
--
作者：
Hou, Yan-long;Yang, Xiao-lan;You, Chong-ge
背景本研究的目的是确定高甘油三酯血症和高尿酸血症 (HUA) 之间的关联。方法本研究在 3884 名未接受药物治疗的受试者中进行，作为基线。每位参与者在2011年至2017年间至少接受3次年度健康检查。使用多元调整logistic回归模型根据TG水平以四个四分位数（Q1至Q4）评估高尿酸血症的风险。结果HUA总发病率为62.3/1000人年。单因素分析显示，高甘油三酯血症患者发生高尿酸血症的风险是甘油三酯正常者的2.353倍，95%置信区间为（2.011，2.754）；男性发生高尿酸血症的风险是女性的1.86倍，95%置信区间为（1.634，2.177）。调整潜在混杂因素后，TG在Q2、Q3、Q4的相对风险RR分别为1.445（95%CI：1.114，1.901）、2.075（1.611，2.674）、2.972（2.322，3.804）。结论TG是高尿酸血症的独立危险因素。随着 TG 水平的升高，HUA 的风险也会增加。
BackgroundThe aim of this study was to determine the association between hypertriglyceridemia and hyperuricemia (HUA).MethodsThe study was conducted in 3884 subjects who had not received medication enrolled as a baseline. Each participant received at least three annual health check-ups between 2011 and 2017. The risk of hyperuricemia was assessed in four Quartiles (Q1 to Q4) according to TG levels using multivariate-adjusted logistic regression models.ResultsThe total incidence rate of HUA was 62.3/1000 person-years. In the univariate analysis, the risk of hyperuricemia in people with hypertriglyceridemia was 2.353 times that of normal triglycerides, with a 95% confidence interval of (2.011, 2.754), and the risk of hyperuricemia in men was 1.86 times of female, and the 95% confidence interval is (1.634, 2.177). After adjusting the potential confounders, the relative risk RR of TG at Q2 Q3 Q4 was 1.445 (95%CI:1.114, 1.901), 2.075 (1.611, 2.674), 2.972 (2.322, 3.804).ConclusionsTG is an independent risk factor for hyperuricemia. As the level of TG increases, the risk of HUA increases.