Development of a drug delivery system for the treatment of periodontal disease based on bioerodible poly(ortho esters).
Development of a drug delivery system for the treatment of periodontal disease based on bioerodible poly(ortho esters).
复制标题
开发基于生物可蚀聚原酸酯的治疗牙周病的药物递送系统。
DOI：
10.1016/0142-9612(95)93259-g
复制
发表时间：
1995
期刊：
影响因子：
14
通讯作者：
Heller,J
中科院分区：
文献类型：
--
作者：
Roskos,KV;Fritzinger,BK;Rao,SS;Armitage,GC;Heller,J
由1，2，6-己三醇和原乙酸烷酯缩合而成的聚(邻酯)在室温下是粘性的半固体材料，可以用钝针注射。当四环素被加入到这些材料中时，大约在24小时内完全释放，而当少量的Mg(OH)2被加入到聚合物中时，释放可以延长到数周，0.5wt%的负载量导致大约10天的持续释放。当使用牛牙测试粘附性时，纯聚合物在约392mNcm−2的力下发生粘结失效，而含有10wt%四环素和1wt%(Mg(OH)2)的聚合物在约118mNcm−2时发生粘结失效。可注射性、牙本质粘附性和精确控制所含抗生素的释放的组合使这些材料有望成为用于牙周炎治疗的可生物侵蚀递送系统的候选材料。毒理学研究目前正在进行中。
Poly(ortho esters) prepared by the condensation of 1,2,6-hexanetriol and an alkyl orthoacetate are viscous, semisolid materials at room temperature that can be injected using a blunt needle. When tetracycline was incorporated into these materials, complete release occurred within about 24 hours, but when small amounts of Mg(OH)2were incorporated into the polymer release could be extended to many weeks, and a loading of 0.5wt% resulted in sustained release of about 10 days. When adhesion was tested using bovine teeth, cohesive failure of the pure polymer occurred at a force of about 392 mNcm−2and cohesive failure of a polymer incorporating 10wt% tetracycline and 1 wt% (Mg(OH)2occurred at about 118 mNcm−2. The combination of injectability, dentoadhesiveness and ability to control accurately the release of incorporated antibiotics makes these materials promising candidates for bioerodible delivery systems useful in the treatment of periodontitis. Toxicological studies are currently in progress.