Effects of some atypical antidepressants on beta-adrenoceptor binding and adenylate cyclase activity in the rat forebrain.
Effects of some atypical antidepressants on beta-adrenoceptor binding and adenylate cyclase activity in the rat forebrain.
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一些非典型抗抑郁药对大鼠前脑中β-肾上腺素受体结合和腺苷酸环化酶活性的影响。
DOI：
10.1016/0014-2999(85)90276-6
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发表时间：
1985
影响因子：
5
通讯作者：
T. B. Weeramanthri
中科院分区：
文献类型：
--
作者：
G. Garcha;R. Smokcum;J. Stephenson;T. B. Weeramanthri
The effects of daily administration to rats of desipramine, talsupram, tomoxetine, maprotiline, nomifensine, mianserin and citalopram (each 10 mg kg−1day−1) for 4 weeks on [3H]dihydroalprenolol ([3H]DHA) binding in the cerebral cortex and on the noradrenaline-sensitive adenylate cyclase in the limbic forebrain were determined. Of these compounds, desipramine was alone in reducing [3H]DHA binding and in attenuating the cAMP response. Two selective noradrenaline uptake inhibitors, talsupram and tomoxetine each reduced the cAMP response but without affecting [3H]DHA binding. The other drugs lacked effect on both measures indicating (except for citalopram) that reduction in sensitivity of β-adrenoceptors and of the noradrenaline-sensitive cAMP response might not be a simple consequence of noradrenaline uptake inhibition. The lack of effect of citalopram on the sensitivity of the β-adrenoceptor system suggests that antidepressants with selective 5-HT uptake inhibitory properties owe their antidepressant activity to other mechanisms.
影响因子：
--
作者：
D. Charney;D. Menkes;G. Heninger
通讯作者：
D. Charney;D. Menkes;G. Heninger
影响因子：
5.8
作者：
F. Sulser;J. Vetulani;P. Mobley
通讯作者：
F. Sulser;J. Vetulani;P. Mobley