Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science
Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science
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DOI：
10.1016/j.clp.2018.09.007
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发表时间：
2019-03-01
影响因子：
2.1
通讯作者：
Good, Misty
中科院分区：
文献类型：
--
作者：
Mihi, Belgacem;Good, Misty
坏死性小肠结肠炎（NEC）仍然是早产婴儿死亡的主要原因。NEC是多因素的，被认为是肠道不成熟、微生物生态失调和炎症反应旺盛的结果。在过去的十年中，早产儿未成熟肠道中toll样受体4 （TLR4）活性的升高是NEC发生前的一个刺激事件。上皮细胞中TLR4信号的增加导致不受控制的免疫反应的启动和粘膜屏障的破坏。本文讨论了NEC期间tlr4介导炎症的分子机制的科学现状以及预防NEC的新治疗策略的发展。
Necrotizing enterocolitis (NEC) remains a leading cause of preterm infant mortality. NEC is multifactorial and believed a consequence of intestinal immaturity, microbial dysbiosis, and an exuberant inflammatory response. Over the past decade, exaggerated Toll-like receptor 4 (TLR4) activity in the immature intestine of preterm neonates emerged as an inciting event preceding NEC. Increased TLR4 signaling in epithelial cells results in the initiation of an uncontrolled immune response and destruction of the mucosal barrier. This article discusses the state of the science of the molecular mechanisms involved in TLR4-mediated inflammation during NEC and the development of new therapeutic strategies to prevent NEC.