SMP-domain proteins at membrane contact sites: Structure and function.
SMP-domain proteins at membrane contact sites: Structure and function.
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DOI：
10.1016/j.bbalip.2015.12.003
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
De Camilli P
中科院分区：
文献类型：
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作者：
Reinisch KM;De Camilli P
SMP结构域存在于定位于膜接触部位的蛋白质中。对这些蛋白质性质的阐明提供了发生在这些部位的潜在过程的分子基础的线索。本文介绍了最近在内质网-质膜和内质网-线粒体接触的延伸突触素蛋白和Ermes复合亚单位的结构、功能和调控方面的最新发现。它们充当有助于这些部位的结构的纽带，并作为脂类转运体在相对的膜之间传送甘油脂。
SMP-domains are found in proteins that localize to membrane contact sites. Elucidation of the properties of these proteins gives clues as to the molecular bases underlying processes that occur at such sites. Described here are recent discoveries concerning the structure, function, and regulation of the Extended-Synaptotagmin proteins and ERMES complex subunits, SMP-domain proteins at endoplasmic reticulum (ER)- plasma membrane and ER-mitochondrial contacts, respectively. They act as tethers contributing to the architecture of these sites and as lipid transporters that convey glycerolipids between apposed membranes.