Estimation of 24-Hour Sodium Excretion from Spot Urine Samples
Estimation of 24-Hour Sodium Excretion from Spot Urine Samples
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DOI：
10.1111/j.1751-7176.2009.00241.x
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发表时间：
2010-03-01
影响因子：
2.8
通讯作者：
Gerber, Linda M.
中科院分区：
文献类型：
--
作者：
Mann, Samuel J.;Gerber, Linda M.
尽管钠摄入量对血压和抗高血压药物的反应有影响，但在临床实践中很少监测钠摄入量。目前的方法，24小时尿液收集钠排泄，是繁琐的，往往不正确的执行，并不常见的命令。此外，由于钠摄入量的日常变化，其结果的意义有限。一个点尿试验，使方便，廉价，连续监测钠排泄将是可取的。在这项研究中，预测24小时钠排泄量的准确性从一个点尿样本进行了评估。尿钠/肌酐比值由以下尿液样本确定：“AM样本”，在24小时尿液采集开始时提交;“PM样本”，在下午晚些时候/晚餐前傍晚采集，大致在采集的中点;以及“随机样本”，在完成后采集。然后根据24小时肌酐排泄量校正比值。在中点附近采集的PM样本中，观察到24小时钠排泄量预测值与实际值之间的最强相关性（r=0.86，P
Despite the effects of sodium intake on blood pressure and on response to antihypertensive medication, sodium intake is rarely monitored in clinical practice. The current method, the 24-hour urine collection for sodium excretion, is cumbersome, often incorrectly performed, and not commonly ordered. Further, its results have limited meaning because of the substantial day-to-day variation in sodium intake. A spot urine test to enable convenient, inexpensive, and serial monitoring of sodium excretion would be desirable. In this study, the accuracy of predicting 24-hour sodium excretion from a spot urine sample was assessed. The urine sodium/creatinine ratio was determined from the following urine samples: an "AM sample," submitted at the beginning of the 24-hour urine collection; a "PM sample" collected in the later afternoon/early evening before dinner, at roughly the midpoint of the collection; and a "random sample," collected after its completion. The ratio was then corrected for 24-hour creatinine excretion. The strongest correlation between predicted and actual 24-hour sodium excretion was observed with the PM sample collected near the midpoint (r=0.86, P