Learning from agriculture: understanding low-dose antimicrobials as drivers of resistome expansion.
Learning from agriculture: understanding low-dose antimicrobials as drivers of resistome expansion.
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DOI：
10.3389/fmicb.2014.00284
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发表时间：
2014
影响因子：
5.2
通讯作者：
Silbergeld EK
中科院分区：
文献类型：
--
作者：
You Y;Silbergeld EK
抗生素耐药性是全球范围内日益严重的公共卫生挑战，抗生素的农业使用是抗生素耐药性（AMR）出现和传播的主要原因之一。在全球范围内，大多数抗菌剂用于工业食用动物生产，这是微生物组遇到来自所有机械类别的低剂量或亚治疗水平抗菌剂的主要背景。这种现代做法对食用动物的肠道微生物组产生了广泛的生态进化影响，随后转移到动物粪便中。这些废物含有复杂的成分，难以处理，包括AMR决定因素和低剂量抗菌剂。大量动物废弃物的无限制储存或土地沉积导致其与环境的广泛接触，并通过移动组促进基因水平转移来驱动环境抗性组的扩张。扩大的环境抗性组包括自然成分和人为输入，在农业的多重压力下可能持续存在，并可能重新进入人类，从而对人类构成公共卫生风险。由于这些原因，本文重点介绍农业抗菌药物的使用，作为一个实验室，了解低剂量抗菌药物作为耐药基因组扩展的驱动程序，简要总结了目前对这一主题的认识，强调了研究的重要性，特别是对环境微生物生态系统考虑AMR的环境污染，并呼吁注意在系统水平上的纵向研究的需要。
Antimicrobial resistance is a growing public health challenge worldwide, with agricultural use of antimicrobials being one major contributor to the emergence and dissemination of antimicrobial resistance (AMR). Globally, most antimicrobials are used in industrial food animal production, a major context for microbiomes encountering low-doses or subtherapeutic-levels of antimicrobial agents from all mechanistic classes. This modern practice exerts broad eco-evolutionary effects on the gut microbiome of food animals, which is subsequently transferred to animal waste. This waste contains complex constituents that are challenging to treat, including AMR determinants and low-dose antimicrobials. Unconfined storage or land deposition of a large volume of animal waste causes its wide contact with the environment and drives the expansion of the environmental resistome through mobilome facilitated horizontal genet transfer. The expanded environmental resistome, which encompasses both natural constituents and anthropogenic inputs, can persist under multiple stressors from agriculture and may re-enter humans, thus posing a public health risk to humans. For these reasons, this review focuses on agricultural antimicrobial use as a laboratory for understanding low-dose antimicrobials as drivers of resistome expansion, briefly summarizes current knowledge on this topic, highlights the importance of research specifically on environmental microbial ecosystems considering AMR as environmental pollution, and calls attention to the needs for longitudinal studies at the systems level.
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影响因子：
64.8
作者：
Beaber, JW;Hochhut, B;Waldor, MK
通讯作者：
Waldor, MK
影响因子：
10.4
作者：
Ashbolt NJ;Amézquita A;Backhaus T;Borriello P;Brandt KK;Collignon P;Coors A;Finley R;Gaze WH;Heberer T;Lawrence JR;Larsson DG;McEwen SA;Ryan JJ;Schönfeld J;Silley P;Snape JR;Van den Eede C;Topp E
通讯作者：
Topp E
影响因子：
2.8
作者：
Andrews, RE;Johnson, WS;Marvin, JD
通讯作者：
Marvin, JD
DOI：
10.1126/science.1220761
发表时间：
2012-08-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Forsberg KJ;Reyes A;Wang B;Selleck EM;Sommer MO;Dantas G
通讯作者：
Dantas G
影响因子：
6.4
作者：
Allen HK;Looft T;Bayles DO;Humphrey S;Levine UY;Alt D;Stanton TB
通讯作者：
Stanton TB