Long-term survival in childhood acute leukemia: "late" relapses.
Long-term survival in childhood acute leukemia: "late" relapses.
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儿童急性白血病的长期生存：“晚期”复发。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
K. Starling
中科院分区：
文献类型：
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作者：
V. Land;D. Berry;J. Herson;T. Miale;H. Ried;M. Silva;K. Starling
研究了83名儿童急性白血病的“晚期”复发模式，这些儿童首次连续完全缓解超过3年，然后随机分配停止治疗（40名患者）或继续治疗（43名患者）共6年。83例中有20例（22.9%）复发：10例在骨髓，1例在中枢神经系统，9例在睾丸。男性停止治疗3年时睾丸复发率为41.1%(7/17)，远高于继续治疗3年时的8.7%（2/23）。这一差异在P = 0.01时具有显著性（Wilcoxon检验）。
The "late" relapse patterns of childhood acute leukemia were studied in 83 children in their first continuous complete remission for more than three years prior to randomization for stopping therapy (40 patients) or continuing therapy (43 patients) for a total of six years. Twenty of 83 (22.9%) have relapsed: Ten in the bone marrow, one in the central nervous system, and nine in the testes. The testes relapse rate of 41.1% (7/17) in males discontinuing therapy at three years was much higher than that of 8.7% (2/23) in males continuing therapy. This difference is significant at P = 0.01 (Wilcoxon test).