Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?
Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?
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DOI：
10.1016/j.schres.2012.01.035
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发表时间：
2012-05-01
影响因子：
4.5
通讯作者：
Dazzan, Paola
中科院分区：
文献类型：
--
作者：
Aas, Monica;Navari, Serena;Dazzan, Paola
精神病患者有较高的儿童期创伤发生率，这也与对认知功能的不良影响有关，如注意力，注意力和精神速度，语言和言语智力。虽然这种关联的病理生理学基础尚不清楚，但这些认知缺陷可能代表了在杏仁核和海马等结构中观察到的与创伤暴露相关的变化的功能相关性。有趣的是，这些结构经常被报道为在精神病中改变。本研究调查了首发精神病患者童年创伤、认知功能与杏仁核和海马体积之间的关系。我们调查了83例首发精神病患者和63名健康对照。所有参与者都接受了GE Sigma 1.5-T系统采集的MRI扫描，以及一般认知、记忆、处理速度、执行功能、视觉空间能力、言语智力和语言的标准化神经心理学评估。在一个子样本的患者（N=45）的信息，儿童期创伤收集的照顾和虐待问卷（CECA）的童年经历。Q）。我们发现，杏仁核，但不是海马，体积显着较小（p=0.001）的患者相比，健康对照组。组和性别之间的海马体积存在趋势水平相互作用（p=0.056）。童年创伤史与认知能力差和杏仁核体积小有关。这个较小的杏仁核似乎调解了精神病患者童年创伤与执行功能，语言和言语智力表现之间的关系。这指出了儿童期创伤暴露、认知功能和首发精神病患者杏仁核体积之间的复杂关系。(C)2012爱思唯尔有限公司版权所有。
Patients with psychosis have higher rates of childhood trauma, which is also associated with adverse effects on cognitive functions such as attention, concentration and mental speed, language, and verbal intelligence. Although the pathophysiological substrate for this association remains unclear, these cognitive deficits may represent the functional correlate of changes observed in relation to trauma exposure in structures such as the amygdala and the hippocampus. Interestingly, these structures are often reported as altered in psychosis. This study investigated the association between childhood trauma, cognitive function and amygdala and hippocampus volume, in first-episode psychosis. We investigated 83 patients with first-episode psychosis and 63 healthy controls. All participants underwent an MRI scan acquired with a GE Sigma 1.5-T system, and a standardized neuropsychological assessment of general cognition, memory, processing speed, executive function, visuo-spatial abilities, verbal intelligence, and language. In a subsample of the patients (N=45) information on childhood trauma was collected with the Childhood Experience of Care and Abuse Questionnaire (CECA. Q). We found that amygdala, but not hippocampus, volume was significantly smaller (p=0.001) in patients compared to healthy controls. There was a trend level interaction for hippocampus volume between group and sex (p=0.056). A history of childhood trauma was associated with both worse cognitive performance and smaller amygdala volume. This smaller amygdala appeared to mediate the relationship between childhood trauma and performance on executive function, language and verbal intelligence in patients with psychosis. This points to a complex relationship between childhood trauma exposure, cognitive function and amygdala volume in first-episode psychosis. (C) 2012 Elsevier B.V. All rights reserved.