Primary colorectal signet-ring cell carcinoma: Clinicopathological features and postoperative survival
Primary colorectal signet-ring cell carcinoma: Clinicopathological features and postoperative survival
复制标题
DOI：
10.1007/s00595-009-4057-y
复制
发表时间：
2010-03-01
期刊：
影响因子：
2.5
通讯作者：
Nishida, Toshirou
中科院分区：
文献类型：
--
作者：
Mizushima, Tsunekazu;Nomura, Masaya;Nishida, Toshirou
本研究的目的是探讨原发性结直肠印戒细胞癌的临床病理特征和术后生存率。从1993年至2007年在大阪大学医院及其附属医院接受手术治疗的5884例结直肠癌手术患者的数据库中确定了19例原发性结直肠癌印戒细胞癌患者。将这些患者的临床病理资料与5792例非印戒细胞结直肠癌患者的临床病理资料进行比较（5417例为高分化或中分化腺癌，375例为低分化腺癌或粘液癌）。所有患者肿瘤深度均大于T3。14例患者发生淋巴结受累。19例患者中有7例在诊断时出现远处转移。原发性印戒细胞癌的总体5年生存率为24.1%，而高分化或中分化腺癌为77.5%，低分化腺癌或粘液癌为57.7%。同样，III期患者的术后生存率也明显较差。另一方面，在II期和iv期没有明显的差异。原发性结直肠印戒细胞癌最重要的特征是在诊断时处于晚期。此外，术后生存率比其他类型的结直肠癌差。
The objective of this study was to investigate the clinicopathological features and postoperative survival of primary colorectal signet-ring cell carcinoma.Nineteen patients with primary colorectal signet-ring cell carcinoma were identified from a database of 5884 surgical patients with colorectal cancers treated surgically at Osaka University Hospital and affiliated hospitals between 1993 and 2007. The clinicopathological data of those patients were compared with those of 5792 patients with non-signet-ring cell colorectal carcinoma (5417 with well or moderately differentiated adenocarcinoma and 375 with poorly differentiated adenocarcinoma or mucinous carcinoma).All patients showed a tumor depth of over T3. Lymph node involvement occurred in 14 patients. Seven of 19 patients presented with distant metastasis at the time of diagnosis. The overall 5-year survival rate in primary signet-ring cell carcinoma was significantly lower at 24.1%, in comparison to 77.5% in well or moderately differentiated adenocarcinoma and 57.7% in poorly differentiated adenocarcinoma or mucinous carcinoma. Likewise, the postoperative survival in Stage III was also significantly worse. On the other hand, no significant difference was observed in Stage II or IV.The most important feature of primary colorectal signet-ring cell carcinoma is the advanced stage at the time of diagnosis. In addition, the postoperative survival is worse than for other types of colorectal cancer.