Difluorotoluene, a nonpolar isostere for thymine, codes specifically and efficiently for adenine in DNA replication
Difluorotoluene, a nonpolar isostere for thymine, codes specifically and efficiently for adenine in DNA replication
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DOI：
10.1021/ja963718g
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发表时间：
1997-02-26
影响因子：
15
通讯作者：
Kool, ET
中科院分区：
文献类型：
--
作者：
Moran, S;Ren, RXF;Kool, ET
聚合酶将核苷酸掺入DNA的高度特异性对于维持细胞复制中信息传递的保真度至关重要。初始插入事件是避免基因组突变的第一个点。1，2在此步骤中，不匹配配对仅发生在103中的101的级别上
The high specificity of incorporation of nucleotides into DNA by polymerase enzymes is crucial for maintaining fidelity of information transfer in cellular replication. The initial insertion event is the first point at which mutations of the genome are avoided. 1, 2 Mismatched pairing at this step occurs on the level of only∼ 1 in 103