Serial Review: Role of Reactive Oxygen and Nitrogen Species (ROS/RNS) in Lung Injury and Diseases Guest Editor: Brooke T. Mossman REACTIVE OXYGEN SPECIES IN PULMONARY INFLAMMATION BY AMBIENT PARTICULATES
Serial Review: Role of Reactive Oxygen and Nitrogen Species (ROS/RNS) in Lung Injury and Diseases Guest Editor: Brooke T. Mossman REACTIVE OXYGEN SPECIES IN PULMONARY INFLAMMATION BY AMBIENT PARTICULATES
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发表时间：
2003
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通讯作者：
F. Tao;B. González-Flecha;L. Kobzik
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作者：
F. Tao;B. González-Flecha;L. Kobzik
暴露于环境空气污染颗粒物（PM）与心肺发病率和死亡率增加有关，特别是在已有疾病的个体中。易感人群肺部炎症加重（例如，哮喘患者、COPD患者）似乎是PM发挥其毒性的中心机制。空气动力学直径为2.5 m（PM2.5）的PM对健康的影响最为一致，尽管10 m PM 2.5 m也可能有毒。通过其金属、半醌、脂多糖、烃和超细组分，PM可以通过呈递或通过刺激细胞产生活性氧（ROS）来对肺中的细胞施加氧化应激。在体内，PM增加细胞因子和趋化因子释放、肺损伤和中性粒细胞流入。体外分析PM对关键细胞靶点、肺泡巨噬细胞、上皮细胞和中性粒细胞的影响，证实PM和氧化剂依赖性反应与体内数据一致。这些影响已经在多年收集的PM样本以及真实的时间收集的浓缩PM 2.5（CAPs）中观察到。ROS介导的氧化应激是PM致肺炎症的重要机制。© 2003 Elsevier Inc.关键词-自由基，氧化应激，环境空气颗粒，肺泡巨噬细胞，上皮细胞，中性粒细胞
Exposure to ambient air pollution particles (PM) has been associated with increased cardiopulmonary morbidity and mortality, particularly in individuals with pre-existing disease. Exacerbation of pulmonary inflammation in susceptible people (e.g., asthmatics, COPD patients) appears to be a central mechanism by which PM exert their toxicity. Health effects are seen most consistently with PM with aerodynamic diameter 2.5 m (PM2.5), although 10 m PM 2.5 m can also be toxic. Through its metal, semi-quinone, lipopolysaccaride, hydrocarbon, and ultrafine constituents, PM may exert oxidative stress on cells in the lung by presenting or by stimulating the cells to produce reactive oxygen (ROS). In vivo, PM increase cytokine and chemokine release, lung injury, and neutrophil influx. In vitro analysis of PM effects on the critical cellular targets, alveolar macrophages, epithelial cells, and neutrophils, demonstrates PMand oxidant-dependent responses consistent with in vivo data. These effects have been observed with PM samples collected over years as well as concentrated PM 2.5 (CAPs) collected in real time. Oxidative stress mediated by ROS is an important mechanism of PM-induced lung inflammation. © 2003 Elsevier Inc. Keywords—Free radicals, Oxidative stress, Ambient air particles, Alveolar macrophages, Epithelial cells, Neutrophils