Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
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DOI：
10.1038/bjc.1981.115
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发表时间：
1981-06
影响因子：
8.8
通讯作者：
Butler LJ
中科院分区：
文献类型：
--
作者：
Easty DM;Easty GC;Carter RL;Monaghan P;Butler LJ
从36例头颈部鳞状细胞癌患者的手术标本中建立了10个人舌和喉鳞状细胞癌细胞系，目的是为研究头颈部鳞状细胞癌的侵袭性和组织破坏能力提供系统。对这10个品系的形态、超微结构和生长特性进行了描述。前4个品系的详细细胞遗传学分析表明，每个品系的核型都是独特的，没有交叉污染的证据。10种细胞系中有9种在培养基中分泌免疫反应性β人绒毛膜促性腺激素（β-hCG）。细胞系分泌纤溶酶原激活物的能力与其在软琼脂中生长或作为免疫缺陷小鼠异种移植物的能力之间没有相关性。
Ten cell lines of human squamous carcinomas of the tongue and larynx have been established from surgical specimens removed from 36 unselected patients, in order to provide systems for investigating the invasive and tissue-destructive capacity of squamous carcinomas of the head and neck. The morphology, ultrastructure and growth characteristics of the 10 lines are described. Detailed cytogenetic analysis of the first 4 lines indicates that each is karyotypically unique, with no evidence of cross-contamination. Nine of the 10 cell lines secrete immunoreactive beta human chorionic gonadotrophin (beta-hCG) in the culture medium. No correlation was demonstrated between the ability of the cell lines to secrete plasminogen activator and their capacity to grow in soft agar or as xenografts in immune-deficient mice.