Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid
Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid
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DOI：
10.1053/j.gastro.2005.12.029
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发表时间：
2006-03-01
期刊：
影响因子：
29.4
通讯作者：
Rodés, J
中科院分区：
文献类型：
--
作者：
Parés, A;Caballería, L;Rodés, J
背景和目标：由于UDCA对原发性胆汁性肝硬化（PBC）长期结局的疗效尚未完全阐明，我们评估了接受UDCA治疗的PBC患者的病程和生存期，并与马约模型预测的生存期和标准化人群的估计生存期进行了比较。方法：（192例PBC患者[181名女性]接受UDCA [15 mg/kg/天]治疗1.5-14年。）治疗应答定义为：治疗1年后碱性磷酸酶降低超过基线值的40%或正常水平。通过马约模型获得预测的生存期，估计的生存期取自标准化匹配的西班牙人群。结果：17例患者死亡或符合肝移植标准（8.9%）。观察到的生存率高于马约模型的预测值，低于对照组（P
Background & Aims: Because the efficacy of UDCA on long-term outcome of primary biliary cirrhosis (PBC) has not been completely elucidated, we have assessed the course and survival of patients with PBC treated with UDCA and compared with the survival predicted by the Mayo model and the estimated survival of a standardized population. Methods: (One hundred ninety-two patients [181 women] with PBC treated with UDCA [15 mg/kg per day] for 1.5-14 years.) Response to treatment was defined by an alkaline phosphatase decrease greater than 40% of baseline values or normal levels after :1 year of treatment. The predicted survival was obtained by the Mayo model and the estimated survival was taken from the standardized matched Spanish population. Results: Seventeen patients died or fulfilled criteria for liver transplantation (8.9%). The observed survival was higher than that predicted by the Mayo model and lower than that of the control population (P