ZIP CODES DIRECT INTRACELLULAR PROTEIN-TYROSINE PHOSPHATASES TO THE CORRECT CELLULAR ADDRESS
ZIP CODES DIRECT INTRACELLULAR PROTEIN-TYROSINE PHOSPHATASES TO THE CORRECT CELLULAR ADDRESS
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DOI：
10.1016/0968-0004(94)90274-7
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发表时间：
1994-04-01
影响因子：
13.8
通讯作者：
DIXON, JE
中科院分区：
文献类型：
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作者：
MAURO, LJ;DIXON, JE
跨膜和细胞内蛋白酪氨酸磷酸酶（PTP）作为参与各种细胞过程（包括分裂、增殖和分化）的信号转导蛋白发挥着重要作用。因此，必须严格调节它们的活性，以避免细胞蛋白的非特异性酪氨酸去磷酸化。细胞内 PTP 在催化结构域之外拥有多种蛋白质序列，这些序列似乎充当“邮政编码”，专门将这些蛋白质“寻址”到定义的亚细胞区室。这些定位策略被提议作为一种调节机制，定义细胞内 PTP 的底物特异性和功能。
The transmembrane and intracellular protein tyrosine phosphatases (PTPs) play an essential role as signal transduction proteins involved in various cellular processes including division, proliferation and differentiation. As such, their activity must be strictly regulated to avoid nonspecific tyrosine dephosphorylation of cellular proteins. The intracellular PTPs possess a diversity of protein sequences outside the catalytic domain that appear to serve as 'zip codes' specifically 'addressing' these proteins to defined subcellular compartments. These localization strategies are proposed to function as a regulatory mechanism, defining the substrate specificity and function of the intracellular PTPs.