Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: A cross-sectional analysis of the US adult AIDS clinical trials group
Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: A cross-sectional analysis of the US adult AIDS clinical trials group
复制标题
DOI：
10.1086/339042
复制
发表时间：
2002-03-15
影响因子：
11.8
通讯作者：
Rajicic, N
中科院分区：
文献类型：
--
作者：
Sherman, KE;Rouster, SD;Rajicic, N
丙型肝炎病毒（HCV）已成为人类免疫缺陷病毒（HIV）感染患者肝损伤和肝衰竭的重要病原体。HCV在HIV感染患者的代表性队列中的患病率和特征尚未描述。因此，对1687例HIV感染患者的代表性样本进行了研究;通过使用基于风险的抽样，从2项大型前瞻性美国成人艾滋病临床试验组临床试验中选择了213例样本子队列。确定了HCV患病率、HCV RNA水平和基因型。研究队列中HCV患病率的加权总体估计值为16.1%（95%加权置信区间，14.3%-17.8%），根据风险因素和HIV RNA水平存在显着差异。在被定义为“高危”的患者中，72.7%为HCV阳性，而在低危患者中，阳性率为3.5%。在83.3%的感染患者中发现基因1型。中位HCV RNA水平为6.08 × 10（6）IU/mL。高病毒载量和基因型1的流行可能是重要的干扰素为基础的抗病毒反应率在合并感染的患者。
Hepatitis C virus (HCV) has emerged as an important etiologic agent of liver injury and failure in patients infected with human immunodeficiency virus (HIV). The prevalence and characteristics of HCV in a representative cohort of HIV-infected patients have not been described. Therefore, a representative sample of 1687 HIV-infected patients was studied; a 213-sample subcohort was selected by use of risk-based sampling from 2 large prospective US Adult AIDS Clinical Trials Group clinical trials. HCV prevalence, HCV RNA level, and genotype were determined. The weighted overall estimate of HCV prevalence in the study cohort was 16.1% (95% weighted confidence interval, 14.3%-17.8%), with significant variability depending on risk factors and HIV RNA levels. Among patients defined as being "at risk," 72.7% were HCV positive, whereas, among low-risk patients, the positivity rate was 3.5%. Genotype 1 was found in 83.3% of infected patients. Median HCV RNA level was 6.08 x 10(6) IU/mL. High virus loads and genotype 1 prevalence may be important to interferon-based antiviral response rates among coinfected patients.