High-resolution magnetic resonance imaging for detection of carotid plaques
High-resolution magnetic resonance imaging for detection of carotid plaques
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DOI：
10.1227/01.neu.0000195097.31033.66
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发表时间：
2006-02-01
期刊：
影响因子：
4.8
通讯作者：
Hayashi, T
中科院分区：
文献类型：
--
作者：
Honda, M;Kitagawa, N;Hayashi, T
目的：我们报告我们的经验，使用高分辨率磁共振成像（MRI），以确定颈动脉斑块，并讨论这些MRI结果，同时将其与颈动脉内膜切除术samples.METHODS：18颈动脉斑块从17个不同的患者使用斑块MRI观察。患者包括14名男性和3名女性，年龄53至75岁（平均68.6岁）。8例患者发生卒中，4例患者发生短暂性脑缺血发作。其余5名患者未出现任何神经系统症状。二维飞行时间（TOE）磁共振血管造影; T1加权成像;脂肪抑制，心脏门控，黑血质子密度成像;和T2加权成像获得了1.5-T MRI。结果：症状斑块显示巨大或部分点状高信号的每一个对比。飞行时间和T2加权成像的高信号强度预测斑块的不稳定性（100%的敏感性和特异性）。特别是，飞行时间成像预测斑块内扩张的灵敏度为100%，特异性为80%。MRI显示4个无症状病变中有3个为不稳定斑块。结论：高分辨率MRI能够检测与斑块成分相关的各种信号模式，因此被认为对评价斑块不稳定性非常有用。因此，斑块MRI的应用可能会积极影响决策过程时，选择最佳的治疗策略来治疗颈动脉斑块。
OBJECTIVE: We report our experience using high-resolution magnetic resonance imaging (MRI) to identify carotid plaques and also discuss these MRI findings while comparing them with carotid endarterectomy specimens.METHODS: Eighteen carotid plaques from 17 different patients were observed using plaque MRI. The patients included 14 men and 3 women, aged 53 to 75 years (mean, 68.6 yr). Eight patients experienced a stroke and four patients experienced transient ischemic attack. The remaining five patients did not experience any neurological symptoms. Two-dimensional time-of-flight (TOE) MR angiography; T1-weighted imaging; fat-suppressed, cardiac gated, black-blood proton density imaging; and T2-weighted imaging were obtained with a 1.5-T MRI.RESULTS: Symptomatic plaques showed either vast or partially dotted high signals for each contrast. The high signal intensity on time-of-flight and T2-weighted imaging predicted the instability of the plaques (100% sensitivity and specificity). In particular, time-of-flight imaging predicted intraplaque hemorrhaging with 100% sensitivity and 80% specificity. MRI revealed that three of four asymptomatic lesions were unstable plaques.CONCLUSION: High-resolution MRI was able to detect various signal patterns related to the plaque components, and it was thus considered to be very useful for evaluating plaque instability. The application of plaque MRI therefore may positively affect the decision-making process when selecting optimal therapeutic strategies to treat with carotid plaques.