Hepatitis C virus genotype 1a NS5A pretreatment sequence variation and viral kinetics in African American and white patients.
Hepatitis C virus genotype 1a NS5A pretreatment sequence variation and viral kinetics in African American and white patients.
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非裔美国人和白人患者中丙型肝炎病毒基因型 1a NS5A 预处理序列变异和病毒动力学。
DOI：
10.1086/432760
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Wolinsky,StevenM
中科院分区：
文献类型：
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作者：
Layden-Almer,JenniferE;Kuiken,Carla;Ribeiro,RuyM;Kunstman,KevinJ;Perelson,AlanS;Layden,ThomasJ;Wolinsky,StevenM
在丙型肝炎病毒(丙型肝炎病毒)感染中，种族是治疗反应和干扰素(干扰素)有效性的决定因素。在这里，我们调查了非洲裔美国人患者和白人患者的治疗前病毒株是否存在差异，以及这些差异是否与病毒动力学有关。用病毒动力学模型计算干扰素的有效性。对21例丙型肝炎病毒1a亚型治疗患者的NS5A区进行了序列测定和分析。白人患者在V3区域有更多的突变(Mean±SD，4.5±1.4对2.9±1.6；P=.016)，治疗应答者比无应答者在该区域有更多的突变。干扰素疗效与V3区突变数呈显著正相关(P=0.03)。在系统发育分析中，没有根据种族、治疗反应或干扰素有效性对菌株进行聚类。这项研究的结果与之前一项说明非裔美国人干扰素有效性受损的研究结果相结合，表明了宿主相关因素的作用
In hepatitis C virus (HCV) infection, race is a determinant of treatment response and interferon (IFN) effectiveness. Here, we investigated whether there were differences in the pretreatment viral strains between African American patients and white patients and whether these differences correlated with viral kinetics. IFN effectiveness was calculated using a viral kinetic model. The HCV NS5A region from 21 treated patients with HCV genotype 1a was sequenced and analyzed. White patients displayed more mutations in the V3 region (mean±SD, 4.5±1.4 vs. 2.9±1.6; P=.016), and treatment responders tended to have more mutations in this region than did nonresponders. There was a significant positive correlation between IFN effectiveness and the number of mutations in the V3 region (P=.03). There was no clustering of strains by race, treatment response, or IFN effectiveness in phylogenetic analyses. The results of this study, in conjunction with those of a previous study illustrating the impaired IFN effectiveness in African Americans, suggest a role for host-related factors