Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes.
Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes.
复制标题
认知功能下降与患有 1 型糖尿病的老年患者之前发生的严重低血糖和血糖控制受损有关。
DOI：
10.1007/s13340-022-00588-9
复制
发表时间：
2022
期刊：
影响因子：
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通讯作者：
et al.
中科院分区：
文献类型：
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作者：
Shigemoto S;Imagawa A;et al.
本研究旨在阐明老年1型糖尿病患者的认知功能与血糖控制的关系。材料与方法45例老年1型糖尿病患者，年龄74.9 ± 6.7岁，糖化血红蛋白水平7.9 ± 0.9%。33%的患者发生严重低血糖，认知功能测试前5年内发生严重低血糖的次数为0.6 ± 1.2。采用修订后的长谷川痴呆量表(HDS-R)、简易智力状态检查(MMSE)和社区综合护理系统痴呆评定表(DASC-21)对患者的临床资料和痴呆评分进行分析。严重低血糖发作次数分别与HDS-R、MMSE和DASC-21显著相关。当有严重低血糖经历的组与对照组进行比较时，在调整年龄模型协方差分析后，HDS-R、MMSE和DASC-21有显著差异。结论在老年1型糖尿病患者中，我们的结果表明，认知功能测试中过去5年的高HbA1c和从疾病诊断时起有严重低血糖发作的病史与认知功能下降有关。
Aim/IntroductionThis investigation aimed to clarify the relationship between cognitive function and blood glucose control in the elderly individuals with type 1 diabetes.Materials and methodsIn total, 45 patients with type 1 diabetes, age 74.9 ± 6.7 years, and HbA1c levels of 7.9 ± 0.9% were studied. Severe hypoglycemia occurred in 33% of patients, and the number of severe hypoglycemia episodes was 0.6 ± 1.2 in the past 5 years before the time of the cognitive function tests. We analyzed clinical data and dementia scores on the Revised Hasegawa’s Dementia Scale (HDS-R), Mini-Mental State Examination (MMSE), and Dementia Assessment Sheet for Community-based Integrated Care System, and 21 items (DASC-21).ResultsThere was a significant correlation between HbA1c and HDS-R, MMSE, respectively. There was a significant correlation between the number of severe hypoglycemic episodes and HDS-R, MMSE, and DASC-21, respectively. When the group with experience of severe hypoglycemia was compared to the control group, HDS-R, MMSE, and DASC-21 were meaningfully different after adjusting for age modeling analysis of covariance.ConclusionsIn elderly individuals with type 1 diabetes, our results suggest that high HbA1c for the past 5 years from the cognitive function test and a history of severe hypoglycemic episodes from the time of disease diagnosis are related to decreased cognitive function.