Prognostic impact of histological subtype on surgically treated localized renal cell carcinoma.
Prognostic impact of histological subtype on surgically treated localized renal cell carcinoma.
复制标题
DOI：
10.1016/j.juro.2009.07.019
复制
发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Russo P
中科院分区：
文献类型：
--
作者：
Teloken PE;Thompson RH;Tickoo SK;Cronin A;Savage C;Reuter VE;Russo P
Please try later.
Despite the clear demonstration that different histological subtypes of renal cell carcinoma (RCC) exhibit distinct pathogenesis and genetic alterations, the impact of histology on prognosis remains controversial. We evaluated our experience with tumor histology in patients with localized RCC. We identified 1,863 patients with localized clear cell, papillary, or chromophobe RCC who were treated surgically between 1989 and 2006 at our tertiary care center. Cox proportional hazards regression models were used to evaluate the relationship between tumor histology and outcome-defined as metastasis or death from disease, adjusting for age, sex, operation type, ASA score, TNM stage, and tumor size Among 1,863 patients, 72% (n=1333) had clear cell histology, 17% (n=310) had papillary RCC, and 12% (n=220) had chromophobe RCC. The median follow-up for patients without an event was 3.4 years. Univariately, patients with clear cell histology had worse clinical outcomes: the 5-year probability of freedom from metastases or death from disease was 86% (95%CI: 84%, 88%), 95% (95% CI: 91%, 97%), and 92% (95% CI: 85%, 96%) for patients with clear cell, papillary, or chromophobe histology, respectively (p < 0.001). On multivariate analysis chromophobe and papillary histology were also significantly associated with better outcome (HR chromophobe 0.40 (95% CI 0.20, 0.80); HR papillary 0.62 (95% CI: 0.34, 1.14); p=0.014). Clear cell histology seems to be independently associated with worse outcomes in patients undergoing surgical treatment for RCC even after controlling for widely accepted factors influencing prognosis.
登录
查看更多内容
影响因子：
6.6
作者：
Kattan, MW;Reuter, V;Russo, P
通讯作者：
Russo, P
DOI：
10.1016/j.urolonc.2007.05.009
发表时间：
2007-09-01
影响因子：
2.7
作者：
Haas, Naomi B.;Uzzo, Robert G.
通讯作者：
Uzzo, Robert G.
影响因子：
6.2
作者：
Lam, JS;Shvarts, O;Belldegrun, AS
通讯作者：
Belldegrun, AS
影响因子：
3.7
作者：
Beck, SDW;Patel, MI;Russo, P
通讯作者：
Russo, P
影响因子：
4.1
作者：
Schuetz, AN;Yin-Goen, Q;Young, AN
通讯作者：
Young, AN