Hypersensitivity syndrome due to trichloroethylene exposure: A severe generalized skin reaction resembling drug-induced hypersensitivity syndrome
Hypersensitivity syndrome due to trichloroethylene exposure: A severe generalized skin reaction resembling drug-induced hypersensitivity syndrome
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DOI：
10.1111/j.1346-8138.2010.01155.x
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发表时间：
2011-03-01
影响因子：
3.1
通讯作者：
Watanabe, Hideaki
中科院分区：
文献类型：
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作者：
Watanabe, Hideaki
在亚洲发展中国家，特别是自20世纪90年代中期以来，患有三氯乙烯（TCE）相关的严重皮肤病并肝功能障碍的患者人数一直在增加。在日本，报告了5例这种疾病，但自20世纪90年代以来没有一例。然而，最近在东京又发现了两例病例。已发表的研究和我们的研究表明，TCE的氧化代谢物可能包括三氯乙酰化蛋白加合物，可引起全身皮肤疹。此外，人类白细胞抗原(HLA)-B*1301和HLA-B*44被确定为个体对tce诱导的过敏综合征（HS）的易感性标志物。此外，TCE代谢的主要酶醛脱氢酶（ALDH）多态性似乎与TCE诱导的HS有关。有趣的是，从接触TCE/药物后的反应开始、临床表现、血液检查和病毒再激活的时间来看，该疾病与药物性超敏反应综合征（DIHS），也称为药物性皮疹伴嗜酸性粒细胞增多和全身症状（DRESS）非常相似。本文综述了tce相关HS与DIHS/DRESS的相似性。
The number of patients suffering from trichloroethylene (TCE)-related severe skin disorders with liver dysfunction has been increasing in developing countries in Asia, especially since the mid-1990s. In Japan, five cases of this disease have been reported, but none since the 1990s. However, two additional cases were recently observed in Tokyo. The published work and our investigation indicated that oxidative metabolites of TCE, which might include trichloroacetylated-protein adducts, could induce a generalized skin eruption. Furthermore, human leukocyte antigen (HLA)-B*1301 and HLA-B*44 were identified as markers of individual susceptibility to TCE-induced hypersensitivity syndrome (HS). Moreover, polymorphism of aldehyde dehydrogenase (ALDH), the major enzyme in TCE metabolism, appeared to be associated with TCE-induced HS. Interestingly, this disorder is quite similar to drug-induced hypersensitivity syndrome (DIHS), also referred to as drug rash with eosinophilia and systemic symptoms (DRESS), from the perspective of the onset of the reaction after exposure to TCE/drugs, clinical manifestations, blood examination and period of virus reactivation. This article reviews the similarity between TCE-related HS and DIHS/DRESS.