Inhibition of hemolysate-induced iNOS and COX-2 expression by genistein through suppression of NF-κB activation in primary astrocytes
Inhibition of hemolysate-induced iNOS and COX-2 expression by genistein through suppression of NF-κB activation in primary astrocytes
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DOI：
10.1016/j.jns.2008.12.007
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发表时间：
2009-03-15
影响因子：
4.4
通讯作者：
Yin, Hong-Xia
中科院分区：
文献类型：
--
作者：
Lu, Hua;Shi, Ji-Xin;Yin, Hong-Xia
染料木素是大豆中主要的异黄酮类化合物。我们研究了金雀异黄素对溶血物处理的原代星形胶质细胞的抗炎作用。结果表明，金雀异黄素可抑制溶血诱导的星形胶质细胞iNOS和COX-2mRNA的表达。此外，该化合物还能抑制溶血物刺激的核因子-kappaB(NF-kappa B)水平。因此，我们认为金雀异黄素对溶血诱导的iNOS和COX-2基因表达的抑制作用可能是在转录水平上抑制了核因子-kappaB的激活。(C)2008爱思唯尔B.V.保留所有权利。
Genistein is a major isoflavone compound from soybean. We investigated the anti-inflammatory properties of genistein in primary astrocytes treated with hemolysate. The results indicated that genistein inhibited the expression of hemolysate induced iNOS and COX-2 mRNA on astrocytes. Furthermore, this compound inhibited the level of hemolysate-stimulated nuclear factor-kappa B (NF-kappa B). Therefore, we suggested that the effect of genistein-mediated inhibition of the expression hemolysate-induced iNOS and COX-2 genes is due to under the suppression of NF-kappa B activation in the transcriptional level. (c) 2008 Elsevier B.V. All rights reserved.