Maternal gestational diabetes, birth weight, and adolescent obesity
Maternal gestational diabetes, birth weight, and adolescent obesity
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DOI：
10.1542/peds.111.3.e221
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发表时间：
2003-03-01
期刊：
影响因子：
8
通讯作者：
Colditz, GA
中科院分区：
文献类型：
--
作者：
Gillman, MW;Rifas-Shiman, S;Colditz, GA
目标。肥胖会增加许多不良后果的风险，但其早期原因尚不清楚。妊娠期糖尿病(GDM)反映了与高出生体重相关的代谢改变的胎儿环境，而高出生体重本身又与后来的肥胖有关。然而，之前关于妊娠期糖尿病和后代肥胖的研究很少，而且相互矛盾。这项研究的目的是检验出生体重和GDM与青少年体重指数(BMI)的关系，并确定GDM的影响在多大程度上是通过其对出生体重的影响来解释的，还是通过母亲的肥胖来解释的。我们对7981名9至14岁的女孩和6900名男孩进行了一项调查，他们是今日成长研究的参与者，这是一项美国全国性的关于饮食、活动和生长的研究。1996年，参与者通过自我管理的邮寄问卷报告了身高、体重、饮食、活动和其他变量。我们将这些数据与他们的母亲、护士健康研究II参与者报告的信息联系起来，包括GDM、身高、当前体重和孩子的出生体重。我们排除了出生人口
Objective. Obesity increases risk of many adverse outcomes, but its early origins are obscure. Gestational diabetes mellitus (GDM) reflects a metabolically altered fetal environment associated with high birth weight, itself associated with later obesity. Previous studies of GDM and offspring obesity, however, have been few and conflicting. The objectives of this study were to examine associations of birth weight and GDM with adolescent body mass index (BMI) and to determine the extent to which the effect of GDM is explained by its influence on birth weight or by maternal adiposity.Methods. We conducted a survey of 7981 girls and 6900 boys, 9 to 14 years of age, who are participants in the Growing Up Today Study, a US nationwide study of diet, activity, and growth. In 1996, participants reported height, weight, diet, activity, and other variables by self-administered mailed questionnaire. We linked these data with information reported by their mothers, participants in the Nurses' Health Study II, including GDM, height, current weight, and child's birth weight. We excluded births