NLRC4/IPAF: a CARD carrying member of the NLR family.
NLRC4/IPAF: a CARD carrying member of the NLR family.
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DOI：
10.1016/j.clim.2008.08.011
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Flavell RA
中科院分区：
文献类型：
--
作者：
Sutterwala FS;Flavell RA
The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Recent findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria. Macrophages infected with Legionella pneumophila, Salmonella typhimurium, Shigella flexneri, or Pseudomonas aeruginosa activate caspase-1 in an NLRC4-dependent manner leading to macrophage cell death and the release of proinflammatory cytokines. This review will discuss these findings as well as the role of bacterial type III and type IV secretion systems and flagellin in NLRC4-mediated caspase-1 activation.
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影响因子：
12.4
作者：
Petrilli, V.;Papin, S.;Tschopp, J.
通讯作者：
Tschopp, J.
DOI：
10.1073/pnas.0708616105
发表时间：
2008-02-05
影响因子：
11.1
作者：
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通讯作者：
Amselem, S.
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16
作者：
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通讯作者：
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158.5
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通讯作者：
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影响因子：
30.8
作者：
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通讯作者：
Slim, R