The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects
The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects
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DOI：
10.1016/s0006-3223(01)01084-8
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发表时间：
2001-09-15
影响因子：
10.6
通讯作者：
Todtenkopf, M
中科院分区：
文献类型：
--
作者：
Benes, FM;Vincent, SL;Todtenkopf, M
背景：最近的一项研究报道，精神分裂症患者大脑前扣带回(ACCx)和前额叶(PfCx)的第II层非锥体神经元(NPs)密度降低，这在分裂情感受试者中最为明显。我们的研究评估了ACCx中NPs的减少是否会显示出与情感障碍更强的协变性。对12名正常对照(CONS)、11名精神分裂症患者和10名年龄与死后时间(PMI)相匹配的双相情感障碍患者进行了队列分析。方法：采用二维技术对横跨ACCx第I层至第VI层的大型x，y抽样柱中的细胞进行计数。结果：双相情感障碍组第二层NPs的密度降低了27%，而精神分裂症组的NPs密度下降了16.2%。精神分裂症组和双相情感障碍组在第三层到第六层的NPs没有差异。这两组受试者在深层椎板中的PNS也显示出适度的下降；然而，这些差异只在精神分裂症受试者的第四层中显著。神经胶质细胞密度在对照组、精神分裂症组和双相情感障碍组中相似。对细胞大小的Abercrombie校正并没有改变结果的性质。在双相情感障碍患者和未接受抗精神病药物治疗的受试者中，双相情感障碍患者大脑皮质第二层NPs或深层神经元中的PNS密度均较低。结论：总体来看，双相情感障碍患者ACCx第二层局部环路细胞减少，而深层投射神经元减少。生物精神病学2001；50：395-406(C)2001生物精神病学学会。
Background: A recent study reported a decreased density of nonpyramidal neurons (NPs) in layer II of the anterior cingulate (ACCx) and prefrontal (PFCx) cortices of schizophrenic brain that was most pronounced in schizoaffective subjects. Our study assessed whether a decrease of NPs in ACCx may show a stronger covariation with affective disorder. A cohort consisting of 12 normal control (CONs), 11 schizophrenic, and 10 bipolar subjects matched for age and postmortem interval (PMI) has been analyzed.Methods: A two-dimensional technique was employed for counting cells in a large x,y sampling column that extended across layers I through VI of ACCx.Results: There was a 27% reduction in the density of NPs in layer II of the bipolar group, whereas in the schizophrenic group, this density was 16.2% lower. There were no differences in NPs in layers III through VI of either the schizophrenic or bipolar group. Both groups also showed modest decreases of PNs in the deeper laminae; however, these differences were only significant in layer IV of the schizophrenic subjects. The density of glial cells was similar across the control, schizophrenic, and bipolar groups. An Abercrombie correction for cell size did not alter the nature of the results. Subjects both with and without neuroleptic exposure showed a lower density of NPs in layer II of bipolar subjects or PNS in deeper laminae of schizophrenic subjects.Conclusions: Overall, the findings reported here suggest that local circuit cells in layer II of ACCx may be decreased in bipolar disorder, whereas projection neurons in deeper laminae are decreased in schizophrenia. Biol Psychiatry 2001;50:395-406 (C) 2001 Society of Biological Psychiatry.