Response to treatment with antidepressants of patients with severe or moderate nonpsychotic depression and of patients with psychotic depression.
Response to treatment with antidepressants of patients with severe or moderate nonpsychotic depression and of patients with psychotic depression.
复制标题
重度或中度非精神病性抑郁症患者和精神病性抑郁症患者对抗抑郁药治疗的反应。
DOI：
10.1176/ajp.147.5.621
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Davis,JM
中科院分区：
文献类型：
--
作者：
Kocsis,JH;Croughan,JL;Katz,MM;Butler,TP;Secunda,S;Bowden,CL;Davis,JM
住院患者分为非精神病性重度抑郁（N= 53），非精神病性中度抑郁（N= 54），精神病性抑郁（N= 25）组，并与丙咪嗪或阿米替林，高达250毫克/天，4周。38名重度抑郁症患者中有39%的患者有良好反应，49名中度抑郁症患者中有67%的患者有良好反应，19名完成治疗的精神病性抑郁症患者中有32%的患者有良好反应。非精神病性重度抑郁症患者的反应与精神病性抑郁症患者的反应没有显著差异，两组的表现都比非精神病性中度抑郁症患者差。
Hospitalized patients were divided into nonpsychotic severely depressed (N= 53), nonpsychotic moderately depressed (N= 54), and psychotic depressed (N= 25) groups and treated with either imipramine or amitriptyline, up to 250 mg/day, for 4 weeks. Good response occurred in 39% of the 38 severely depressed, 67% of the 49 moderately depressed, and 32% of the 19 psychotic depressed patients who completed treatment. The response of the patients with nonpsychotic severe depression did not differ significantly from the response of those with psychotic depression, and both groups fared worse than the group with nonpsychotic moderate depression.