New Compounds from the Roots and Stems of Trigonostemonlii and Their Cytotoxic Activities
New Compounds from the Roots and Stems of Trigonostemonlii and Their Cytotoxic Activities
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DOI：
10.1002/hlca.201600029
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发表时间：
2016-07
影响因子：
1.8
通讯作者：
Yong-Qin Liu;Y. Di;Yue-Hu Wang;X. Hao;Xu-Jia Hu
中科院分区：
文献类型：
--
作者：
Yong-Qin Liu;Y. Di;Yue-Hu Wang;X. Hao;Xu-Jia Hu
从胡芦巴的根和茎中分离得到一个新的卡宾生物碱Trifiline D(1)和一个新的降解二萜类化合物Trigoxyphin X(4)。它们的结构通过包括一维和二维核磁共振技术在内的广泛的波谱分析来确定。化合物1对MCF-7、A-549、MGC-803和Colo-205有较弱的抑制作用，IC50值在27.4~35.4mU/M之间。
A new carboline alkaloid, Trifiline D (1) and a new degraded diterpenoid, Trigoxyphin X (4) were isolated from the roots and stems of Trigonostemonlii. Their structures were elucidated by extensive spectroscopic analyses including 1D- and 2D-NMR techniques. Compound 1 exhibited weak inhibitory activity against MCF-7, A-549, MGC-803, and COLO-205 with IC50 values ranging from 27.4 to 35.4 mu M.