Falsely low LDL-cholesterol concentrations and artifactual undetectable HDL-cholesterol measured by direct methods in a patient with monoclonal paraprotein
Falsely low LDL-cholesterol concentrations and artifactual undetectable HDL-cholesterol measured by direct methods in a patient with monoclonal paraprotein
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DOI：
10.1016/j.cccn.2005.02.008
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发表时间：
2005-08-01
影响因子：
5
通讯作者：
Liu, SF
中科院分区：
文献类型：
--
作者：
Tsai, LY;Tsai, SM;Liu, SF
前言：多发性骨髓瘤是一种伴有脂蛋白异常的恶性免疫增殖性疾病。本文报告1例多发性骨髓瘤伴免疫球蛋白G、单克隆性甲亢和明显高脂血症患者，用直接法检测低密度脂蛋白-胆固醇和人工检测不到的高密度脂蛋白-胆固醇。病例报告：用传统的半定量电泳法测定的高密度脂蛋白-C和低密度脂蛋白-C浓度分别在0.630.71和2.222.36 mmol/L范围内，观察到低密度脂蛋白-C的假低浓度和人工无法检测的高密度脂蛋白-C可能导致多发性骨髓瘤单克隆性甲状旁腺疾病患者的管理不善，结论：用均相法直接测定单抗辅助蛋白阳性多发性骨髓瘤患者的低密度脂蛋白胆固醇和高密度脂蛋白胆固醇时应慎重。(C)2005 Elsevier B.V.保留所有权利。
Introduction: Multiple myeloma is a malignant immunoproliferative disorder with lipoprotein abnormalities. We report a case of falsely low concentrations of LDL-cholesterol (LDL-C) and artifactural undetectable HDL-cholesterol (HDL-C) as measured with direct methods in a patient of multiple myeloma with IgG, monoclonal gammapathy and significant hyperlipidemia.Case report: The patient had HDL-C and LDL-C concentrations in the 0.63 0.71 mmol/l and 2.22 2.36 mmol/l ranges, respectively, as measured by a traditional semi-quantitative electrophoresis method, The observation of falsely low concentrations of LDL-C and artifactural undetectable HDL-C might result in the mismanagement of patients of multiple myeloma with monoclonal gammapathy, because the LDL-C and HDL-C concentrations are positive and negative risk factors of cardiovascular diseases.Conclusions: Care must be taken when using the homogenous method for direct measurement of LDL-cholesterol and HDL-cholesterol in patients of multiple myeloma with monoclonal paraprotein. (c) 2005 Elsevier B.V. All rights reserved.