Multipotent menstrual blood stromal stem cells: Isolation, characterization, and differentiation
Multipotent menstrual blood stromal stem cells: Isolation, characterization, and differentiation
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DOI：
10.3727/096368908784153922
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Allickson, Julie G.
中科院分区：
文献类型：
--
作者：
Patel, Amit N.;Park, Eulsoon;Allickson, Julie G.
许多组织和器官的基质干细胞部分已被证明表现出干细胞特性，如自我更新和多能性的能力，允许多谱系分化。在这项研究中，我们描述了一群来自月经血的基质干细胞（MenSC）。我们证明了MenSC很容易扩展到临床相关性，并在分子和细胞水平上表达多能标记物，如Oct-4，SSEA-4和c-kit。此外，我们通过将MenSC定向分化为软骨形成、脂肪形成、成骨形成、神经形成和心脏形成细胞谱系来证明MenSC的多能性。这些研究证明了MenSC的可塑性，可用于再生医学的潜在研究。
The stromal stem cell fraction of many tissues and organs has demonstrated to exhibit stem cell properties such as the capability of self-renewal and multipotency, allowing for multilineage differentiation. In this study, we characterize a population of stromal stem cells derived from menstrual blood (MenSCs). We demonstrate that MenSCs are easily expandable to clinical relevance and express multipotent markers such as Oct-4, SSEA-4, and c-kit at the molecular and cellular level. Moreover, we demonstrate the multipotency of MenSCs by directionally differentiating MenSCs into chondrogenic, adipogenic, osteogenic, neurogenic, and cardiogenic cell lineages. These studies demonstrate the plasticity of MenSCs for potential research in regenerative medicine.