Does an increase in physiological indexes predict better cognitive performance: the PhyCog randomised cross-over protocol in type 2 diabetes.
Does an increase in physiological indexes predict better cognitive performance: the PhyCog randomised cross-over protocol in type 2 diabetes.
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生理指标的增加是否预示着更好的认知能力：2型糖尿病PhyCog随机交叉方案
DOI：
10.1136/bmjopen-2021-060057
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发表时间：
2022-07-01
期刊：
影响因子：
2.9
通讯作者：
Vallet, Guillaume T.
中科院分区：
文献类型：
--
作者：
Magnon, Valentin;Dutheil, Frederic;Tauveron, Igor;Mille, Jordan;Baker, Julien S.;Brusseau, Valentin;Silvert, Laetitia;Izaute, Marie;Vallet, Guillaume T.
人们对认知训练方案越来越感兴趣，以提高认知能力和预防认知障碍，尽管研究结果不一致。体力活动已被确认在维持或改善认知能力。从心理神经生理学的角度来看，生理指标与认知训练的效果一样，在一定程度上决定了神经元的动力学，影响着认知。本研究的主要目的是检查在2型糖尿病（T2 D）临床干预计划的背景下，改善的生理指标是否可预测改善的认知变量。PhyCog将是一项为期22周的随机对照试验，比较三组之间的认知表现：（1）身体活动（1个月），15天的洗脱，然后认知训练（1个月），（2）认知训练（1个月），15天的洗脱和身体活动（1个月），和（3）主动呼吸条件（心理教育和共振频率呼吸1个月），然后是15天的洗脱期，以及身体活动和认知训练的组合（1个月），以确定预防T2 D相关认知障碍的最有效干预措施。所有参与者将在干预后观察3个月。本研究将纳入共计81例T2 D患者。将在基线（第0周至第0周）、洗脱期间（第5周，第4周后72-96小时）、干预结束时（第10周）和随访结束时（第22周）评估认知能力和生理变量。感兴趣的主要变量将是执行功能、记忆力和注意力。生理测试将涉及非稳态负荷，如心率变异性，微循环，皮质醇和硫酸脱氢表雄酮水平。社会人口和身体组成也将是一个考虑因素。评估者均对结局设盲。为了检验主要假设，将收集生理变量的改善与认知变量（执行力、记忆力和注意力）的改善之间的关系。本方案已获得Est III法国伦理委员会批准（2020-A03228-31）。结果将发表在同行评审的期刊上。NCT 04915339。
There has been a growing interest towards cognitive-training programmes to improve cognition and prevent cognitive impairment despite discrepant findings. Physical activity has been recognised in maintaining or improving cognitive ability. Based on a psychoneurophysiological approach, physiological indexes should partly determine neuronal dynamics and influence cognition as any effects of cognitive training. This study’s primary aim was to examine if improved physiological indexes predict improved cognitive variables in the context of a clinical intervention programme for type 2 diabetes (T2D). PhyCog will be a 22-week randomised controlled trial comparing cognitive performance between three arms: (1) physical activity (1 month), a 15-day wash-out, then cognitive training (1 month), (2) cognitive training (1 month), a 15-day wash-out and physical activity (1 month), and (3) an active breathing condition (psychoeducation and resonance frequency breathing for 1 month), then a 15-day wash-out, and combined physical activity and cognitive training (1 month), allowing to determine the most effective intervention to prevent cognitive impairment associated with T2D. All participants will be observed for 3 months following the intervention. The study will include a total of 81 patients with T2D. Cognitive performance and physiological variables will be assessed at baseline (week 0—W0), during the washout (W5, 72–96 hours after week 4), at the end of the intervention (W10), and at the end of the follow-up (W22). The main variables of interest will be executive function, memory and attention. Physiological testing will involve allostatic load such as heart rate variability, microcirculation, cortisol and dehydroepiandrosterone sulfate levels. Sociodemographic and body composition will also be a consideration. Assessors will all be blinded to outcomes. To test the primary hypothesis, the relationship between improvement in physiological variables and improvement in cognitive variables (executive, memory and attention) will be collected. This protocol was approved by the Est III French Ethics Committee (2020-A03228-31). Results will be published in peer-reviewed journals. NCT04915339.
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DOI：
10.1093/gerona/glz073
发表时间：
2020-04-01
影响因子：
5.1
作者：
Bahar-Fuchs, Alex;Barendse, Marjolein E. A.;Beeri, Michel Schnaider
通讯作者：
Beeri, Michel Schnaider
影响因子：
2.7
作者：
Bright, Peter;Hale, Emily;van der Linde, Ian
通讯作者：
van der Linde, Ian
影响因子：
3.4
作者：
DIENER, E;EMMONS, RA;GRIFFIN, S
通讯作者：
GRIFFIN, S
影响因子：
1.8
作者：
Brewer, Gabrielle J.;Blue, Malia N. M.;Smith-Ryan, Abbie E.
通讯作者：
Smith-Ryan, Abbie E.
影响因子：
--
作者：
BOLLA, KI;LINDGREN, KN;BLEECKER, ML
通讯作者：
BLEECKER, ML