Novel Adenovirus Vectors 'Capsid-Displaying' a Human Complement Inhibitor
Novel Adenovirus Vectors 'Capsid-Displaying' a Human Complement Inhibitor
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DOI：
10.1159/000284368
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发表时间：
2010-01-01
影响因子：
5.3
通讯作者：
Amalfitano, Andrea
中科院分区：
文献类型：
--
作者：
Seregin, Sergey S.;Hartman, Zachary C.;Amalfitano, Andrea
Adenovirus (Ad) vectors are currently the most commonly utilized gene transfer vectors in humans worldwide. Unfortunately, upon contact with the circulatory system, Ads induce several, innate, complement-dependent toxicities that limit the full potential for Ad-based gene transfer applications. Therefore, we have constructed several novel Ad5-based vectors, 'capsid-displaying' as fiber or pIX fusion proteins, a complement-regulatory peptide (COMPinh). These novel Ads dramatically minimize Ad-dependent activation of the human and non-human primate complement systems, as determined by several assays. In summary, our work has shown that a novel COMPinh-displaying Ad5 has the potential for broadening the safe use of Ad vectors in future human applications. Copyright (C) 2010 S. Karger AG, Basel
